This Project Grant award of $781,032 was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The award supports research to understand the interplay between norepinephrine and dopamine circuits in the brain and their role in sex differences related to reward and aversion, including substance use disorders. Specifically, the research aims to map the anatomical and neurochemical distribution of norepinephrine projections from...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is funding research to investigate the role of the glucocorticoid receptor (GR) as a neuromolecular mechanism regulating impulsivity within the prelimbic cortex-nucleus accumbens pathway. The total award amount is $127,635, with a project period from June 17, 2025 to December 31, 2025. The research, conducted by the Regents of the University of Michigan,...
This federal Project Grant award, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to characterize the functions of several transcript variants of the DRD3 gene, which encodes the dopamine D3 receptor, and their roles in regulating cocaine-seeking and taking behavior. The $189,644 award to Wake Forest University Health Sciences will fund two phases of research. In the initial R21 phase, the researchers...
This Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) provides $194,375 to The University of Iowa to conduct research on sex-biased, region-specific regulation of dopamine release and clearance. The project aims to investigate how gonadal hormone signaling influences the functional coupling between dopamine transporters and D2 autoreceptors in the nigrostriatal and mesolimbic dopaminergic circuits, and how this translates to...
This federal Project Grant award, with ID R01DA060250, was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The $1,447,919 award, granted on May 1, 2025, supports research conducted by Pennsylvania State University's Milton S. Hershey Medical Center to investigate the "need-state hypothesis" of cocaine addiction. The research aims to use an animal model to track the development of cocaine addiction, identify the...
This Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to determine the mechanisms by which cocaine affects striatal circuit activity and facilitates cocaine seeking and taking behaviors. The $226,295 award, with a performance period from August 15, 2024 to May 31, 2027, will enable the University of Texas at Austin to: 1) investigate the role of striatal enkephalin in cocaine-induced...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), is providing $174,029.99 to the University of California, Irvine to investigate the role of the GILZ gene in regulating cocaine-induced cellular activity and cocaine-associated memory formation. The research aims to elucidate how the GILZ gene, which is located on the X chromosome, may contribute to sex-dependent differences in responses to...
The National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), awarded a $118,656 Project Grant to the Ponce Medical School Foundation Inc. (doing business as Ponce School of Medicine) in Puerto Rico. The grant, awarded on November 29, 2024, supports research to investigate the influence of fear conditioning and cocaine exposure on cocaine-seeking behavior in male and female rats. The project aims to analyze the synaptic changes in the...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $438,750 to the University of California, San Diego (UCSD) to investigate pre-existing differences in GABAergic and glutamatergic transmission within the central amygdala and their potential contribution to individual differences in cocaine addiction susceptibility. The study aims to characterize and compare basal GABAergic and...
This $234,000 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research at Oregon Health & Science University (OHSU) to investigate rapid protein translation in nucleus accumbens neurons in response to a cocaine-associated cue. The goal is to use translating ribosome affinity purification and RNA sequencing (TRAP-seq) to identify mRNAs that are actively translating during re-exposure to cocaine...