Project Grant R03HS027667

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to develop new antimicrobial agents and combination therapies to combat the growing threat of Gram-negative bacterial pathogens, specifically carbapenem-resistant Acinetobacter baumannii (CRAB) and Klebsiella pneumoniae (CRKP). The $2,308,174 award, with a performance period from August 2024 to May 2029, will fund three...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $259,461 to investigate the mechanisms of resistance and clinical outcomes of non-carbapenemase producing carbapenem-resistant Klebsiella pneumoniae (NCP-KPN) infections. The key objectives are to: 1) characterize the genomic factors associated with discordant carbapenem susceptibility phenotypes in a large...

This $294,244 Project Grant award, funded by the Department of Health and Human Services (DHHS) Agency for Healthcare Research and Quality (AHRQ) under the Research on Healthcare Costs, Quality and Outcomes (CFDA 93.226) program, supports research to identify sepsis phenotypes associated with antibiotic-resistant pathogens. The project aims to leverage machine learning techniques, including large language models applied to clinical notes, to augment electronic health record (EHR) data and define...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 aims to develop a platform for detecting genetic antibiotic resistance motifs that can predict current and future susceptibility to therapeutics. The project will establish the feasibility of leveraging mutational signatures in bacterial DNA to identify antibiotic resistance status, including the potential for rapid development of multi-drug resistance. This approach...

This federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to leverage metagenomic next-generation sequencing (MNGS) to study pathogen transmission and antimicrobial resistance (AMR) gene dynamics in a neonatal intensive care unit (NICU) setting. The $197,748 award to The Regents of the University of California, San Francisco will support the following key research...

This three-year National Science Foundation project grant of $799,491 will fund research into the role of horizontal gene transfer in the evolution of antibiotic resistance among bacterial communities. The University of Washington will receive the funding to conduct three related research aims. First, the researchers will propagate communities of Escherichia coli, Salmonella enterica, and Klebsiella pneumoniae bacteria and monitor the evolution of a plasmid-borne gene conferring beta-lactam...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $462,500.00 to St. Jude Children's Research Hospital Inc. from January 1, 2025 to November 30, 2029 to conduct research on deciphering the genetic regulation of bacterial heterogeneity in response to antibiotic stress using single-cell transcriptomics. The key products and services to be delivered under this award include:...

This federal Project Grant award totaling $810,312.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will fund research to investigate environmental reservoirs and transmission dynamics of multi-drug resistant Enterobacterales (MDR ENT) in the Chicago area. The key objectives are to: 1) Profile MDR ENT and mobile antibiotic resistance genes in Greater Chicago waterways to identify environmental...

This Project Grant award, ID R01AI175440, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $728,695 grant, awarded on Sep 1, 2024, will fund research at the University of Arkansas for Medical Sciences (UAMS) to investigate mechanisms of antibiotic resistance and heteroresistance to the novel cephalosporin antibiotic cefiderocol in carbapenem-resistant Gram-negative pathogens. The...

This $205,000 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will fund research at Princeton University examining the influence of chromosome copy number on Pseudomonas aeruginosa persistence to fluoroquinolone antibiotics. The researchers hypothesize that the number of chromosome copies in individual P. aeruginosa cells affects their ability to survive fluoroquinolone...