Project Grant R03HD123297
- The National Institute of Child Health and Human Development awarded Northwestern University $240,000 on September 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.HDR) to develop ovarian somatic organoids as a drug discovery model for reproductive longevity. The research addresses ovarian aging, characterized by loss of egg quantity and quality leading to infertility and altered endocrine function. The funded work builds on the recipient's...
- The National Institute on Aging awarded Northwestern University $400,000 on June 15, 2026, under the Aging Research program (CFDA 93.866) to investigate dysregulated ovulatory debris clearance as a driver of ovarian fibroinflammaging. The research examines age-related failure in the ovary's mechanisms to remove cellular debris accumulated through follicular growth, ovulatory rupture, and corpus luteum regression, and tests whether enhancing debris clearance mechanisms can improve ovarian...
- The National Institute on Aging awarded the Buck Institute for Research on Aging $821,486 on August 15, 2026, under the Aging Research program (CFDA 93.866) to investigate how diet and reproductive status interact to influence ovarian aging and systemic healthspan in fruit flies and humans. The research integrates large-scale human population datasets with mechanistic studies in Drosophila melanogaster. In the first aim, the recipient will leverage human datasets and plasma proteomics to...
- The National Institute of Child Health and Human Development awarded The Washington University $922,870 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865, Assistance Listing 93.HDR). The award funds research to define the molecular mechanisms by which age-associated increases in ovarian tissue stiffness drive follicle inflammation and impair oocyte quality and fertility. The research tests the hypothesis that follicles detect age-related...
- The National Institute of Child Health and Human Development awarded the University of Vermont $436,003 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support research linking genetic variation to the continuum of lifelong ovarian function. The research uses the Collaborative Cross mouse model to explore genetic drivers of ovarian aging and reproductive senescence. The work characterizes the ovarian aging continuum by analyzing...
- The National Institutes of Health National Institute on Aging awarded $681,020 to Magee-Womens Research Institute and Foundation on June 15, 2026, under the Aging Research program (CFDA 93.866) to investigate microbial regulation of type 2 immunity in ovarian tissue remodeling and fibrosis. The research challenges the paradigm that reproductive decline results from inevitable follicle depletion, instead identifying ovarian tissue fibrosis as an environmentally modifiable process driven by...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Trustees of Columbia University in the City of New York $149,190 on August 6, 2026, under the Aging Research program (CFDA 93.866) to investigate the molecular mechanisms by which NBR2, a long non-coding RNA, contributes to ovarian aging. The research addresses female-specific health conditions through genome-wide association studies and functional genomic studies in human ovarian cell models. The...
- The National Institute on Aging awarded Oklahoma Medical Research Foundation $1,422,958 on March 15, 2026, under the Aging Research program (CFDA 93.866) to investigate inflammatory and immune mechanisms driving ovarian tissue aging. The project examines how innate and adaptive immune components contribute to chronic, low-grade inflammation and structural tissue remodeling in the ovary during aging. Research focuses on NF-kB signaling in granulosa cells and its role in orchestrating a...
- The National Institute of Child Health and Human Development awarded Yale University $1.396 million on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate centromere integrity and cytoskeletal function in oocyte aneuploidy and reproductive aging. The award funds research using mouse oocytes to analyze how centromere proteins (including CENP-A and CENP-C), centromeric DNA composition, and microtubule-associated proteins interact to...
- The National Institute of Child Health and Human Development awarded The Regents of The University of Colorado (University of Colorado-Denver) $584,626 on July 8, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to define mechanisms regulating functional regionalization of the mammalian ovary during fetal and perinatal development. Using three-dimensional imaging, computational analyses, and single-cell-scale spatial transcriptomics, the research...
The National Institute of Child Health and Human Development awarded the Buck Institute for Research on Aging $194,000 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate ovarian aging through the three-dimensional lymphatic network. The research examines how the lymphatic vasculature contributes to ovarian function across adulthood and aging, with focus on three-dimensional lymphatic structure and function and interactions between lymphatic vasculature and ovarian follicles. The project addresses a critical gap in understanding the ovarian microenvironment's evolution with age—specifically, how a dysfunctional lymphatic system contributes to the inflammatory signature observed in aged ovaries and subsequent reproductive decline. Work is performed in Novato, California. The period of performance runs from September 1, 2026, through August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $194.0k | 8/13/26 |