This federal Project Grant award from the Fogarty International Center (CFDA 93.989 - International Research and Research Training) provides $559,341 to support research on tuberculosis (TB) in children under 5 years old in Malawi. The award period is from September 20, 2024 to August 31, 2029. The research focuses on two key objectives: 1) evaluating the accuracy of new non-invasive TB diagnostic strategies using stool and urine samples in hospitalized Malawian children under 5, and 2)...
This Project Grant award of $774,881, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Program (CFDA 93.855), supports research to develop pro-apoptotic small molecule host-directed therapies (HDTs) for the treatment of pulmonary tuberculosis (TB). The research aims to utilize these novel HDTs to shorten TB treatment duration, enhance antibiotic penetration, and prevent post-TB lung disease. The project leverages...
This federal Project Grant award of $756,077, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports a 5-year research study on the long-term immunologic, cardiovascular, metabolic, and neurocognitive consequences of inflammation in children with perinatal HIV in sub-Saharan Africa. The primary objectives are to assess the durability of inflammation and immune...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $209,750 to Emory University to leverage antibody-omics technologies to prevent and detect tuberculosis (TB) in children affected by HIV. The key objectives are to: 1) Define antibody Fc features associated with protection from Mycobacterium tuberculosis (MTB) infection in infants with and without maternal HIV exposure, and 2) Identify...
This federal Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) aims to improve strategies for post-cesarean surgical site infection (SSI) monitoring by validating and updating two existing image-based diagnostic algorithms. The $741,747 award will support the prospective follow-up of 6,000 women across three countries (Rwanda, Ghana, and Mexico) to assess the generalizability of the...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $193,316 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Boston Medical Center Corporation (BMC) on August 20, 2024. The award will fund a 5-year research project titled "The Relationship Between HIV Exposure, Contact Networks, and TB in Children Under 5 Years Old." As part of this project, BMC will collaborate with Stellenbosch University in South Africa, which...
This Project Grant award from the John E. Fogarty International Center (CFDA 93.989 - International Research and Research Training) provides $108,237 to Mbarara University of Science and Technology in Uganda to develop and assess the feasibility of a diagnostic tool for post-tuberculosis (TB) lung disease that can be deployed in primary healthcare settings. The key objectives are to: (1) create and validate a clinical diagnostic algorithm for post-TB lung disease, (2) conduct qualitative...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), provides $1,350,312 to develop a rapid phenotypic drug susceptibility test (termed TRE-DST) for tuberculosis (TB). The TRE-DST system utilizes novel fluorescent trehalose probes to detect live Mycobacterium tuberculosis and determine drug resistance, addressing limitations of current diagnostic methods. Key...
This federal Project Grant award of $325,000 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 Child Health and Human Development Extramural Research supports research investigating the effects of government-led cash transfer programs on health outcomes among women and young children in low- and middle-income countries. The research team at the University of Pennsylvania will use longitudinal mortality data from 37 countries to...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to characterize the burden, severity, and phenotypic presentation of post-tuberculosis (TB) lung disease (PTLD) and its association with interleukin-6 (IL-6) signaling pathways in TB patients with and without HIV. The total funding amount is $743,698.00 over the award period from Sep 20, 2024 to Aug 31, 2029. The grant will leverage an...