Crcns: computational mechanisms for state-driven active sensing
Active Project Grant Awarded Last action
- Award ID
- R01NS147767
- Recipient
-
The Johns Hopkins University UEI FTMTDMBR29C7
- Awarding agency
-
National Institute of Neurological Disorders and Stroke
National Institutes of Health, Department of Health and Human Services
- Obligated
- $777,153
Award facts
- Assistance listing
- 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders
- Completion date 26% complete
- Place of performance
- Baltimore, MD 21218, USA
Award details come from USAspending.gov.
Description
- Abstract
- (see instructions): humans and other animals exhibit a critical behavioral phenomenon in the control of movement: they switch between two distinct modes-fast, exploratory active sensing and slower, goal-directed task control. This proposal aims to uncover the computational, behavioral, and neural mechanisms that regulate these two modes. We hypothesize that animals use internal estimates of sensory uncertainty to decide when to switch between modes, with uncertainty thresholds triggering transitions between exploratory and goal-driven behavior. To test this, we will use a uniquely tractable animal model-weakly electric fish performing a refuge tracking task-in which behavior, sensory feedback, and neurophysiology can be measured and manipulated in real time. The project comprises three specific aims: (1) develop computational models and theoretical tools to identify how and why animals switch between active sensing and task control modes; (2) conduct high-throughput behavioral experiments to quantify how sensory salience and feedback influence mode switching and control strategies; and (3) perform neurophysiological recordings to identify neural correlates of locomotor control policies and mode switching in the brain. This multidisciplinary effort integrates control theory, machine learning, and neuroscience to reveal the computational strategies underlying the regulation of active sensing and task control. Our findings have the potential to transform our understanding of biological motor control, identify mechanisms for assessing sensory uncertainty, and advance strategies for movement control in complex environments.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $368,014 | |
| Amendment | $41,250 | |
| Original award | $367,889 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Regents Of The University Of Minnesota | $198,919 | |
| University Of Maryland Baltimore County | $85,250 | |
| New Jersey Institute Of Technology | $225,750 |
Quick answers
Who received award R01NS147767?
R01NS147767 was awarded to The Johns Hopkins University by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on August 1, 2025.
How much is award R01NS147767 worth?
$777,153 has been obligated on R01NS147767.
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