The Philadelphia College of Osteopathic Medicine (PCOM) received a $438,365 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant funds a research project titled "Defining the Role of CD38 and Its Potential as a Therapeutic Target in SBMA" that aims to investigate the role of the enzyme CD38 in the pathogenesis of spinal and bulbar muscular atrophy (SBMA), a neuromuscular disease. The research will use state-of-the-art stem cell technology and CRISPR gene editing to analyze metabolic alterations in SBMA patient-derived cells, and evaluate the potential for CD38 inhibition to restore energy metabolism and motor function in SBMA mouse models. The grant award period runs from January 1, 2025 to December 31, 2029.
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