The National Institute of Mental Health (NIMH) awarded a $1,330,652 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the University of Washington to conduct a hybrid type-1 effectiveness-implementation trial of the "Motivation Matters!" (MM!) mHealth intervention. The goal is to evaluate the safety and effectiveness of MM!, a theory-based mobile health intervention, for achieving undetectable viral load in HIV-positive African women engaged in sex work who...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund a cluster randomized controlled trial to test the impact of a long-term, dynamic choice intervention on 12-month viral suppression among HIV clients experiencing treatment interruption in Malawi. The $653,677 award will be used to implement this research initiative over a project period from April 1, 2025 to January 31, 2030. The goal is to...
The National Institute of Mental Health (NIMH) awarded a $780,447 Project Grant (CFDA 93.242 - Mental Health Research Grants) to Brigham & Women's Hospital Inc. to test a differentiated service delivery model called CARES-DSD to improve engagement and viral suppression among people with HIV who have experienced treatment interruptions in South Africa. The 5-year project will recruit 300 participants from an ongoing study and evaluate the effectiveness of the CARES-DSD intervention compared...
The National Institute of Mental Health (NIMH) awarded a $1,300,224 Project Grant under the Mental Health Research Grants (CFDA 93.242) program to The Johns Hopkins University to conduct a study titled "HOMELINK2: Reducing Posthospitalization Mortality Among People Living with HIV Through Structured Home Care and Nutritional Supplementation." The project aims to evaluate the effectiveness of a home-based intervention involving structured post-hospitalization home visits with...
The National Institute of Mental Health (NIMH) awarded a $898,186 Project Grant under the Mental Health Research Grants (CFDA 93.242) program to Spotted TECH LLC, a woman-owned small business based in Louisiana. The grant, titled "CD4-LINK: Improving Access to HIV Care in Underserved Areas with a Home-Based, Mail-In CD4 Count Test," aims to develop an innovative self-collected dried blood spot (DBS) test kit that would allow people living with HIV to monitor their CD4 counts from home,...
This $262,627 Project Grant award from the National Institute of Mental Health (CFDA 93.242 Mental Health Research Grants) supports the development and testing of a novel peer navigator mHealth intervention to increase uptake of pre-exposure prophylaxis (PrEP) and modern contraception among female university students in Zambia. The key products and services to be delivered under this grant include: Adapting an existing app, PEBRA, using human-centered design and qualitative methods to create a...
The University of California, Los Angeles (UCLA) was awarded a $183,179 Project Grant by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to conduct the "REMIT" study - "Reducing Mobility-Associated Interruption in ART Among Men in Malawi". The project aims to refine and pilot an intervention to improve antiretroviral treatment (ART) outcomes among mobile men living with HIV in Malawi. Key components of the...
The National Institute of Mental Health (NIMH) awarded a Project Grant (CFDA 93.242 - Mental Health Research Grants) totaling $707,796 to the Regents of the University of California, San Francisco (UCSF) to build on the success of the "Malkia Klabu" (MK) loyalty program and evaluate strategies for scaling the program's HIV prevention services for adolescent girls and young women (AGYW) in sub-Saharan Africa. The key products and services to be delivered under this grant include: 1)...
This $452,376 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to develop a predictive model for identifying HIV patients at risk of disengaging from medical care. The University of Chicago is conducting this 2-year project, which has two key objectives: Determine the performance of a Natural Language Processing (NLP) model for predicting loss to follow-up (LTFU) from HIV care across...
This $221,635 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support a community-engaged modeling and implementation science project to develop re-linkage interventions for Black sexual minority men with HIV. The project aims to use agent-based modeling, qualitative data, and implementation science methods to characterize barriers to HIV care engagement and identify strategies to improve re-linkage,...
The National Institute of Mental Health (NIMH) awarded a Project Grant under the Mental Health Research Grants (CFDA 93.242) program to The Washington University in the amount of $1,325,208 on August 9, 2024. The grant will fund a Sequential Multiple Assignment Randomized Trial (SMART) to assess different sequential combinations of strategies to return individuals with HIV treatment lapses to care and reengage them long-term in Zambia.
The key products/services to be delivered include:
Comparing the effectiveness of phone outreach vs. navigation plus community-based medication delivery on time to ART re-initiation and return to care among 1,270 individuals.
Among those who return to care, comparing the effectiveness of routine care, navigation alone, and navigation plus community-based medication delivery on retention in care.
Assessing the overall effectiveness and cost-effectiveness of the six sequential combination return-and-reengage strategies on viral suppression at 18 months.
Conducting a mixed-methods evaluation to understand implementation, mechanisms of action, and sustainability potential.
The project involves sub-awards to the Centre for Infectious Disease Research in Zambia (CIDRZ) to oversee all study activities in Zambia, and to the Seoul National University and Johns Hopkins University to provide specialized research support and evaluation services.