This Project Grant award of $535,153 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund a large-scale, single-cell characterization of molecular and cellular networks involved in mood regulation in major depressive disorder (MDD). The project aims to identify transcriptomic changes associated with MDD in a sample of 800 subjects across three key brain regions: the anterior cingulate cortex, basolateral amygdala, and...
This federal Project Grant award of $729,821, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate the role of long non-coding RNAs (lncRNAs) in the epigenomic reprogramming and transcriptional repatterning associated with major depressive disorder (MDD). The University of Alabama at Birmingham will conduct this 1-year research project to examine how cell type-specific changes in nuclear...
The National Institute of Mental Health (NIMH) awarded a $162,000 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the Research Foundation For Mental Hygiene, Inc. (RFMH), doing business as the New York Psychiatric Center. The project, titled "Transcriptional Diversity of Human Mediodorsal Thalamus and Its Role in Psychiatric Disease", will investigate the transcriptional signatures and genetic factors underlying differences in thalamocortical connectivity...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is providing $2,694,945 to the Lieber Institute for Brain Development to conduct research aimed at understanding the cellular and molecular mechanisms underlying schizophrenia. The key products and services to be delivered include: 1) Replicating and expanding upon prior findings on the association between electrophysiological variables in patient-derived...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $184,476.00 to the University of Southern California to conduct large-scale brain mapping research on bipolar disorder (BD) and major depressive disorder (MDD). The key objectives are to: 1) Apply a standardized voxel-wise brain mapping method across a target sample of 12,000 subjects (3,500 BD, 8,500 healthy controls) to analyze focal morphometric...
The National Institute of Mental Health (NIMH) awarded a $638,872 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to The Feinstein Institutes for Medical Research. The grant, effective January 1, 2025 through December 31, 2029, aims to elucidate how deep brain stimulation (DBS) of the medial forebrain bundle (MFB) modulates the reward network and improves anhedonia (inability to experience pleasure) in patients with treatment-resistant depression. The research will...
The National Institute of Mental Health awarded a three-year Project Grant totaling $3,618,976 to the University of California, Los Angeles under the Mental Health Research Grants program (CFDA 93.242) to develop in situ single-cell multi-omic and morphological profiling methods for mammalian brains. Specifically, the university will work to design photonic-indexing sequencing strategies to spatially barcode tissue with single-cell resolution, integrating techniques such as PI-ATAC-seq and...
This $2,576,654 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support the development of a cloud-based software platform and advanced computational pipelines to harmonize and integrate spatial transcriptomics data for the construction of a spatially resolved brain atlas. Key objectives of the 3-year project include: 1) Creating a cloud-based platform to standardize the analysis and visualization of...
The National Institute of Mental Health (NIMH) awarded a $381,915 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the Icahn School of Medicine at Mount Sinai. The 2-year grant (7/23/2024 - 6/30/2026) will fund research to determine the neural and physiological biomarkers of mood-like states in non-human primates. The project will combine computational models of affect with simultaneous neurophysiology recordings across multiple brain regions to investigate how prediction error...
The National Institute of Mental Health (NIMH) awarded a $823,252 Project Grant (CFDA 93.242 - Mental Health Research Grants) to The Trustees of Princeton University on September 18, 2024. The grant will support a 5-year research project titled "CROSS-BRAIN, MULTI-REGION INTERACTIONS IN DECISION FORMATION AND DECISION COMMITMENT" that aims to enhance the understanding of the neural mechanisms underlying decision-making processes. The grant includes a $55,255 sub-award to The Johns...
The National Institute of Mental Health (NIMH) awarded a $2,220,017 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the Lieber Institute for Brain Development in Baltimore, Maryland. The grant's objective is to generate single-cell transcriptomic profiles to study molecular changes associated with major depressive disorder (MDD) in the mood regulation circuitry of the brain, including the anterior cingulate cortex, basolateral amygdala, and hippocampus. The research aims to identify transcriptomic changes linked to MDD, the impact of genetic ancestry and sex, cell networks associated with mood regulation, and cell-specific expression quantitative trait loci. This large-scale, systematic investigation using an unprecedented sample of 800 human post-mortem brain tissue samples will advance the understanding of the cellular and molecular pathways involved in mood regulation and MDD, potentially leading to novel treatment strategies and personalized interventions.