Phora-pulmonary hypertension outcome risk assessment

Active Project Grant Awarded Sep 1, 2022 Last action Jul 15, 2026

Award ID: R01HL164906
Recipient: Sentara Health UEI LBUCQRCP3C77 Part of The Ohio State University
Awarding agency: National Heart Lung and Blood Institute National Institutes of Health, Department of Health and Human Services
Obligated: $4,368,415

Award facts

Award details come from USAspending.gov.

As the agency reported it.

Abstract: This application seeks to develop improve and expand a multi-platform clinical decision support system (CDSS) in pulmonary arterial hypertension (PAH) for physicians, phora (pulmonary hypertension outcomes risk assessment), which can be used in adults and children to: a) guide therapeutic decisions and B) optimize clinical trial design. We will achieve this goal by utilizing clinical trial data from several large databases of completed trials in PAH, ongoing adult and pediatric PAH registries and biobanks. The proposed aims CO-create the CDSS with a multi-disciplinary group of specialties including: biomedical engineering, advanced PAH, computer science (machine learning/data mining), human computer interaction, and palliative care experts. Our intention is to engage all stakeholders to achieve consensus and thereby assure the acceptance of phora into practice. Successful completion of this project will lay the foundation for a prospective, multi-center meta-registry in which phora will be evaluated with respect to modeling best practice interventions leading to improved long-term patient outcomes. The ultimate aim is to disseminate this resource so as to improve the efficiency, efficacy, and cost-effectiveness of this treatment for PAH.

Show all 48

Subrecipient	Amount	Awarded
The Johns Hopkins University Dr. Everett will provide biomarker data developed in his laboratory on samples from the PAHBiobank. Dr. Everett will development of the PHORA-PEDS risk model.…	$151,434	Apr 23, 2024
Carnegie-Mellon University Using human-centered design methods, such as contextual inquiry, we will examine the clinical and patient decision making processes for patients affected by…	$277,756	Feb 27, 2024
The Ohio State University Dr. Lin and her team will work on the further development of PHORA using state-of-the-art machine learning, deep learning, and statistical methods. This work…	$261,204	Feb 26, 2024

R01HL164906 was awarded to Sentara Health by National Heart Lung and Blood Institute (National Institutes of Health) on September 1, 2022.

$4,368,415 has been obligated on R01HL164906.

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