Effects of early life exposure to household air pollution on DNA methylation and respiratory disease in guatemalan children from the household air pollution intervention network (hapin) trial

Active Project Grant Awarded Last action

Award ID
R01HL163256
Recipient
Awarding agency
Obligated
$4,139,015

Award facts

Assistance listing
93.837 Cardiovascular Diseases Research
Completion date 70% complete
Place of performance
Athens, GA 30602, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Household air pollution (HAP) from solid fuel use causes an estimated 400,000 chronic obstructive pulmonary (copd) deaths each year. Although lung function and lower respiratory disease in childhood are determinants of copd risk later in life, there are few studies of the influence of early life HAP exposure on respiratory health later in childhood. We propose a HAP study design that is sensitive to emerging chronic respiratory effects by incorporating three key features: 1) assessment of exposure during early life windows of susceptibility, 2) a strong exposure contrast introduced by a randomized intervention, and 3) sensitive endpoints that predict chronic disease later in life. Gestation and infancy are critical windows of susceptibility due to the rapid lung development. Previous HAP intervention trials had only low to moderate effectiveness for reducing HAP exposure. The household air pollution intervention network (hapin) trial (2017-2021) offers a time-sensitive, unique research opportunity because the liquefied petroleum gas (LPG) stove and fuel intervention lowered median gestational fine particulate matter (PM2.5) exposure in guatemalan participants by 77%, from 98 to 23 ΜG/M3. The intervention continued until age 1 year and extensive health data were collected, including pneumonia incidence and severity. We have maintained follow-up of the cohort post-intervention, assessing HAP exposure and child growth at age 2 years plus lung function at age 3 years. We posit that childhood lung function and lower respiratory disease episodes are sensitive indicators of HAP health effects that relate to adulthood copd. DNA methylation (dnam) and pneumonia during infancy may influence these respiratory endpoints later in childhood. We propose to leverage our successful LPG cooking intervention in guatemala to investigate effects of early life HAP exposure on longer-term respiratory health and explore dnam as a biomarker. We hypothesize that the randomized LPG cooking intervention and lower PM2.5 and black carbon (BC) exposure will be associated with dnam at age 1 year and greater lung function and fewer lower respiratory disease episodes at age 4-7 years. Aim 1. Estimate effects of a randomized LPG cooking intervention during gestation and infancy (age

Transactions

Action Obligated Date
Amendment $168,452
Amendment $408,435
Amendment $408,435
Amendment $169,619
Amendment $169,619
Amendment $424,320
Amendment $424,320
Amendment $612,961
Amendment $676,427
Original award $676,427

Subawards

Subrecipient Amount Awarded
The Johns Hopkins University Effects of Early Life Exposure to Household Air Pollution on DNA Methylation and Respiratory Disease in Guatemalan Children from the Household Air Pollution… $49,618
The Trustees Of Columbia University In The City Of New York Effects of Early Life Exposure to Household Air Pollution on DNA Methylation and Respiratory Disease in Guatemalan Children from the Household Air Pollution… $78,936
Universidad Del Valle De Guatemala $169,619
Colorado State University $21,134
Universidad Del Valle De Guatemala $163,203
The Trustees Of Columbia University In The City Of New York $179,293
Colorado State University $20,519
The Johns Hopkins University $50,126
Universidad Del Valle De Guatemala $160,933

Quick answers

Who received award R01HL163256?

R01HL163256 was awarded to University Of Georgia Research Foundation, Inc. by National Heart Lung and Blood Institute (National Institutes of Health) on May 15, 2023.

How much is award R01HL163256 worth?

$4,139,015 has been obligated on R01HL163256.

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