Project Grant R01HD123050
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $152,834 to the University of Toledo to study the composition of sperm striated columns and their role in sperm movement and zygote centrosome function. The goal is to identify biomarkers of the striated columns to enable future research on their contributions to male infertility...
- The National Institute of Child Health and Human Development awarded The University of Texas Southwestern Medical Center $500,118 on August 15, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct research on the molecular control of endoplasmic reticulum remodeling during spermiogenesis. The research investigates how spermatids compact the endoplasmic reticulum (ER), the largest intracellular organelle, during the morphological transformation...
- The National Institute of Child Health and Human Development awarded the University of Delaware $336,057 on June 15, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to build a model of the molecular interactions at the fertilization synapse. The award supports research to determine the localization of sperm proteins required for fertilization, identify egg proteins that interact with sperm, and characterize the biochemical interactions between...
- The National Institute of Child Health and Human Development awarded Syracuse University $323,643 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate molecular interactions between the female reproductive tract and sperm that determine fertility. The research characterizes female-derived metabolic proteins and their spatiotemporally regulated interactions with sperm during storage and transit in the female reproductive tract....
- The National Institute of Child Health and Human Development awarded the University of Rochester $149,190 on February 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to investigate the molecular mechanisms of sperm dysfunction induced by meiotic drive. The project combines gene editing, genetic, and cytological approaches to study segregation distorter (SD), a sperm-killing male meiotic driver found in natural populations of Drosophila...
- The National Institute of Child Health and Human Development awarded Yale University $543,572 on August 15, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the molecular mechanisms of sperm-immune recognition in the female reproductive tract. The research addresses how resident macrophages in the female reproductive tract selectively eliminate compromised sperm while permitting viable sperm to reach the egg. The project focuses on...
- The National Institute of Child Health and Human Development awarded $149,190 to The Trustees of The University of Pennsylvania on January 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to determine the postfertilization regulatory functions of a sperm microRNA cluster. The research investigates how sperm microRNAs influence early embryonic development and mediate the paternal transmission of non-genetically inherited phenotypes. The project...
- The National Institute of Child Health and Human Development awarded Yale University $456,999 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the role of acetyl-methyllysine in spermatogenic development. The research characterizes the distribution and regulation of acetyl-methyllysine (KACME), a histone modification combining lysine acetylation and methylation, during sperm development. Aim 1 applies custom anti-KACME...
- The National Institute of Child Health and Human Development awarded the University of Southern California $347,919 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865, Assistance Listing 93.HDR) to decipher the role of RG motifs in piRNA-mediated silencing and transgenerational fertility. The research investigates how arginine/glycine (RG) motifs in PIWI-interacting RNA (piRNA) pathway proteins PRG-1 and HRDE-1 regulate germline gene expression...
- The National Institute of Child Health and Human Development awarded Washington University $125,142 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to study the impact of bacterial vaginosis toxins on sperm function in mice and humans. The research investigates how lipopolysaccharide (a toxin produced by Prevotella) and vaginolysin (a toxin produced by Gardnerella) impair sperm capacitation, hyperactivated motility, and acrosomal...
The National Institute of Child Health and Human Development awarded the University of Toledo $448,793 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate spermatozoa head-kinking mechanics and their role in male fertility. The research addresses molecular and cellular mechanisms underlying human spermatozoa navigation and egg fertilization. The project will employ rabbits as a genetic model and high-resolution microscopy to test the hypothesis that the spermatozoon centrosome dynamically connects the head and tail for efficient fertilization. Specific aims include investigating the relationship between head-kinking and tail-beating across a wide parameter range, determining the role of the POC1B protein and head-kinking in spermatozoa fertilization, and identifying abnormal head-kinking patterns in infertile men. The work represents a paternal mechanism pathway for understanding infertility. Performance occurs at Ottawa Hills, Ohio, with the period of performance running from September 1, 2026, through May 31, 2031. This is a Project Grant, the standard assistance type for NIH research project awards.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $448.8k | 8/26/26 |