Emergence of polycystic ovary syndrome (PCOS) during adolescence

Active Project Grant Awarded Last action

Award ID
R01HD117972
Recipient
Awarding agency
Obligated
$2,029,201

Award facts

Completion date 27% complete
Place of performance
New York, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Polycystic ovary syndrome (PCOS) affects 1 in 8 women of reproductive age imparting reproductive, cardiometabolic and psychological health complications for patients across the lifespan. PCOS is defined by the presence of 2 or more cardinal features including ovulatory dysfunction, hyperandrogenism and polycystic ovarian morphology (PCOM). Although PCOS manifests during adolescence, delays in diagnosis are common as the cardinal features are said to overlap with characteristics of the normal adolescent reproductive transition. Current standards to define PCOS in adolescence differ from those in adulthood - they do not include PCOM owing to a lack of data. This exclusion results in a narrow spectrum of PCOS during adolescence which may not fully capture all with PCOS until 8Y post-menarche when adult-criteria for PCOM are available. Our preliminary data support that ovarian morphology has diagnostic accuracy for PCOS in adolescents and reflects the severity of reproductive and metabolic symptoms in a manner similar to adults. Further, in a longitudinal pilot evaluation of ovarian morphology in healthy adolescents, we show that ovarian markers in the first post-menarcheal year, including anti-müllerian hormone, predict persistent menstrual cycle irregularity at 2Y post-menarche suggesting that morphologic indicators precede in the timeline to aberrant reproductive maturation. We propose that an understanding of the natural history of PCOS during adolescence can provide a framework for the earliest detection and mitigation of this highly prevalent disorder. To that end, this project will define the trajectory of PCOS symptoms during early adolescence (aim 1) and develop a nomogram of ovarian form and function during the first 8 gynecological years (aim 2). Our approach involves elucidating the time course of divergences in ovarian morphology, androgen concentrations and menstrual cyclicity in adolescent cohorts who develop PCOS versus those who establish regular menstrual cycles in the first 3Y post-menarche. Further, we will conduct a cross-sectional analysis of sonographic and serum markers of PCOM across gynecological ages

Transactions

Action Obligated Date
Amendment $638,119
Amendment $0
Amendment $0
Amendment $695,541
Original award $695,541

Subawards

Subrecipient Amount Awarded
Childrens Mercy Hospital Will work closely with the research coordinator and research team consultants to ensure that recruitment is on target. All ultrasound images and clinical data… $156,232
University Of Rochester Participate in the clinical evaluation and screening of participants, including conducting transabdominal ultrasound scans for the study, participate in the… $154,558
Texas A&M Agrilife Research Participate in the clinical evaluation and screening of participants including conducting transabdominal ultrasound scans for the study and participate in the… $112,318
Childrens Mercy Hospital Will work closely with the research coordinator and research team consultants to ensure that recruitment is on target. All ultrasound images and clinical data… $157,050
Texas A&M Agrilife Research Participate in the clinical evaluation and screening of participants including conducting transabdominal ultrasound scans for the study and participate in the… $128,448
University Of Rochester Participate in the clinical evaluation and screening of participants, including conducting transabdominal ultrasound scans for the study, participate in the… $147,406

Quick answers

Who received award R01HD117972?

R01HD117972 was awarded to Cornell University by National Institute of Child Health and Human Development (National Institutes of Health) on August 1, 2025.

How much is award R01HD117972 worth?

$2,029,201 has been obligated on R01HD117972.

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