Project Grant R01HD116631

Award Date 8/9/24
Completion Date 7/31/29
Dollars Obligated $1.4M
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Aurora, CO 80045, USA
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This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), provides $1,376,850 to conduct research on interventions to protect HIV-exposed uninfected (HEU) infants against severe infections. The research aims to:

  1. Define immunogenomic and metabolomic profiles that explain HEU immune dysfunctions;
  2. Compare gut and respiratory microbiome composition and function between HEU and HIV-unexposed infants; and
  3. Test maternal and infant dietary interventions using pasteurized fermented milk to modulate the infant gut microbiome.

The award supports this multi-year research effort led by the University of Colorado-Denver, with sub-awards to the Wits Health Consortium in South Africa and Jackson Laboratory in the U.S. The goal is to identify gut bacterial taxa and metabolites responsible for HEU immune defects that may be mitigated through dietary interventions, ultimately improving immune protection and reducing severe infections, hospitalizations, and mortality in this high-risk infant population.

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