This Project Grant award of $571,213 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research on respiratory and autonomic control dysfunction in a novel rat model of Sudden Infant Death Syndrome (SIDS). The research aims to: Advance the understanding of respiratory and autonomic dysfunction associated with SIDS, Provide a mechanistic perspective on the root causes of...
This federal Project Grant award for $1,994,975.00 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to develop a real-time electrical impedance tomography (EIT) imaging system to guide ventilation strategies and assess bronchodilator responsiveness in infants with bronchopulmonary dysplasia (BPD). The key products and services to be delivered include: 1) building a new 3D EIT...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), is funded under the Cardiovascular Diseases Research program (CFDA 93.837). The $807,067 grant will support a research project titled "Novel Physiomarkers of High-Risk Labored Breathing for Advance Warning of Clinical Deterioration". The primary objective is to develop and validate new quantitative respiratory kinematic markers that can predict the onset...
This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) will allow Washington State University (WSU) to develop advanced musculoskeletal models and simulation approaches to investigate perinatal changes and their impact on musculoskeletal health. The $595,934 award, effective September 1, 2024, will fund research to: (I) determine how pregnancy and postpartum alter torso and hip muscle mechanical properties, (II) assess how spine extensors...
The federal Project Grant award of $2,146,691 was made by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) on August 9, 2024. The grant will fund a study to evaluate the effects of the recently approved prenatal respiratory syncytial virus (RSV) prefusion F protein-based (RSVpref) vaccine on neonatal, lactation, and child health outcomes in up to 20,000 mother-infant dyads across four large...
This $267,000 Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) supports a research project focused on investigating the role of microRNA dysregulation in the brainstem as a potential contributor to Sudden Infant Death Syndrome (SIDS). The research project aims to: 1) Directly examine cell-specific changes in the expression of microRNAs mir-34a-5p and mir-122-5p and their mRNA targets...
This federal Project Grant award of $2,010,598 from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) supports research to examine the association between persistent intergenerational disadvantage and the burden of diarrheal disease and acute respiratory infection among children under five years old. The study will also investigate how disadvantage impacts healthcare utilization and whether spatial remoteness...
This $171,720 Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) supports a research project led by Dr. Nathan Blue at the University of Utah. The project aims to develop individualized prediction models for fetal growth and risk of perinatal morbidity by analyzing maternal genetic information and applying explainable artificial intelligence methods. The specific objectives are to test if...
This federal Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) provides $163,080 to the Ann & Robert H Lurie Children's Hospital of Chicago to conduct research on predicting clinical deterioration in mechanically ventilated children using high-frequency physiological data. The key objectives of this research project are to: 1) derive, validate, and compare longitudinal prediction models...
This Project Grant award, valued at $305,447.00, was provided by the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research program) to identify predictive biomarkers for acute intermittent hypoxia-induced motor recovery in individuals with incomplete spinal cord injury. The key objectives of this research project are to: 1) validate the cellular mechanisms of acute intermittent hypoxia-induced plasticity in humans, and 2)...
This federal Project Grant award, totaling $2,142,743.00, was provided by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865). The purpose of this 5-year grant, beginning July 3, 2024, is to quantify the relationships between biomechanical risk factors and infant respiration in order to reduce sudden unexpected infant deaths.
The research team from Boise State University will conduct in vivo human subject experiments and computational modeling to define how infant body position, product interaction, and feeding affect breathing biomechanics. Key deliverables include analysis of common body positions on infant breathing, computational models to inform safe product design, and characterization of breathing changes after feeding. The project also involves sub-awards to the Arkansas Children's Research Institute for expertise in infant pulmonary mechanics, development assessment, and product safety recommendations.