Project chisoni: a study to define the burden of sudi and its modifiable risk factors in zambia and other african countries

Active Project Grant Awarded Last action

Award ID
R01HD113615
Recipient
Awarding agency
Obligated
$5,530,600

Award facts

Completion date 55% complete
Place of performance
Roxbury, MA 02118, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
In high income countries, sudi, and its sub-categories (1) sudden infant death syndrome (SIDS) and (2) accidental suffocation deaths (ASD), are the leading preventable causes of infant mortality. The ensuing 'back to sleep' campaigns have since proven among the most effective public health strategies ever identified for reducing infant mortality. Yet, in low and middle-income countries (LMICS) almost nothing is known about the burden of sudi or its modifiable risk factors, and very few african countries have policies targeting sudi. In our recent systematic review, we documented a near absence of research on sudi in africa, excepting several well- conducted investigations from south africa. Our focus on sudi emerged during a multi-year postmortem infant surveillance project to establish the fatal burden of respiratory syncytial virus. Over 3 years, we enrolled ~80% of all infant deaths in lusaka, zambia, nearly 2,300 infants. Ultimately, sudi was implicated in 7.4% of those community deaths. Far from being rare, sudi appeared to be a very common cause of infant demise, with modifiable risk factors that were ubiquitous yet wholly unaddressed by existing policies in zambia. If confirmed, sudi constitutes a major unmet opportunity to reduce infant mortality in africa that has largely been ignored by the global health community. Yet, our early data fall short of the gold standard for evaluating sudi deaths. Robust local prevalence data will be essential to support policy initiatives targeting sudi and as a baseline from which to judge the impact of such policies. Therefore, we are proposing project chisoni, a rigorous 5-year study to precisely define the burden of sudi and its modifiable risk factors in zambia. To achieve those broader goals, we have convened a multinational multidisciplinary team with expertise in pediatrics, cause of death analysis, sudi, pathology, molecular biology, and sudi epidemiology. Our aims are: SA1 will create a 'gold standard' evaluation of community infant deaths to demonstrate the burden of sudi in an african setting, which will include in-depth post-mortem evaluations, multiplex PCR to identify unanticipated infectious causes of death and detailed death scene investigations to understand the context in which each death occurred. This will generate the proportion of deaths that are due to sudi and sudi deaths/1000 live births. SA2 includes three sub-aims. SA2.1 will be a matched case-control study examining the association of risk factors with sudi among the cases in SA1 VS. A group of contemporaneously enrolled healthy control infants; SA2.2 takes the ORS and prevalence data from SA1 and S2.1 to calculate the population attributable fraction (PAF) for risk factors alone or in combination, and therefore the theoretical number of lives that could be saved through mitigation; and SA2.3 seeks to expand the generalizability of this project by conducting additional risk factor prevalence surveys in different urban and rural settings in zambia and several other african nations.

Transactions

Action Obligated Date
Amendment $0
Amendment $31,837
Amendment $239,433
Amendment $239,433
Amendment $286,527
Amendment $286,527
Amendment $286,527
Amendment $56,916
Amendment $56,916
Amendment $512,250
Amendment $512,250
Amendment $512,250
Amendment $512,250
Amendment $665,828
Amendment $665,828
Original award $665,828
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Subawards

Subrecipient Amount Awarded
Universitair Medisch Centrum Utrecht Background This Scope of Work describes key activities that University of Utrecht Medical Center has agreed to perform as part of their work on the proposed… $41,982
Avencion LIMITED Year 1 1. Initiate HR processes for hiring local study staff. 2. Coordinate the submission of IRB documentation to the University of Zambia Biomedical… $400,432

Quick answers

Who received award R01HD113615?

R01HD113615 was awarded to Trustees Of Boston University by National Institute of Child Health and Human Development (National Institutes of Health) on March 1, 2024.

How much is award R01HD113615 worth?

$5,530,600 has been obligated on R01HD113615.

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