Real-time EIT pulmonary imaging for infants requiring ventilatory therapy

Active Project Grant Awarded Last action

Award ID
R01HD113290
Recipient
Awarding agency
Obligated
$1,948,859

Award facts

Completion date 62% complete
Place of performance
Fort Collins, CO 80521, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Bronchopulmonary dysplasia (BPD) is the most common morbidity of prematurity with over 10,000 infants diagnosed each year in the united states. Underdeveloped lungs at birth, the need for ventilatory support, which may result in ventilator-induced lung injury, and other factors result in significant structural and functional pulmonary abnormalities associated with short- and long-term lung disease. Effective management includes an individualized approach to choosing the right ventilation strategy and medications. Two important techniques include the use of a long I-time ventilatory strategy and administration of bronchodilators. However, each of these treatments has some associated risk, and there is currently no real-time method to assess their effectiveness on improving ventilation and perfusion. Electrical impedance tomography (EIT) is a noninvasive, non-ionizing real-time functional imaging technique with no harmful side effects, suitable for patients of any age. We hypothesize that EIT images and derived measures can provide real-time, actionable information to guide the clinician's treatment strategy in infants with BPD, and satisfy this unmet need. In this proposal we will carry out the following specific aims: (1) build a new adaptive current tomography system designed for 3D imaging of very young intubated infants including novel 3-D reconstruction algorithms to provide real-time images of regional ventilation, pulsatile perfusion and quantitative EIT-derived measures. (2) assess the ability of EIT images and derived measures to determine the effectiveness of long I-time ventilation strategies while they are being applied. An EIT visualization platform will be developed to enable the clinician to visualize the images and output measures to assess treatment effectiveness. (3) determine what combination of EIT- derived measures provides the best assessment of bronchodilator responsiveness (BDR) in infants with or at risk of BPD after the first administration of bronchodilator therapy. We will evaluate the efficacy in aims 2 and 3 in a study with infants enrolled from the level IV nicu at stanford university medical center and the university of colorado hospital neonatal intensive care unit.

Transactions

Action Obligated Date
Amendment $627,656
Amendment $647,431
Original award $673,772

Subawards

Subrecipient Amount Awarded
The Research Foundation For The State University Of New York Specific Aim 1: Optimize a 3-D multisource adaptive current tomography EIT system for the needs and constraints of imaging very young intubated infants. Design,… $72,597
The Regents Of The University Of Colorado The University of Colorado Denver will provide oversight for all study activities including: assisting in identifying and recruiting research subjects,… $76,770
The Leland Stanford Junior University This collaborative R01 will focus on Aim 1: Optimize a multifrequency EIT system for the needs and constraints of imaging very young intubated infants. Aim 2:… $160,291
GE Medical Systems Information Technologies, Inc. Task for year 1: 1. Develop electrode solution and perform bench test 2. Support the hardware ACT5 optimization, including 1) cable and connection solution 2)… $120,215
The Leland Stanford Junior University This collaborative R01 will focus on Aim 1: Optimize a multifrequency EIT system for the needs and constraints of imaging very young intubated infants. Aim 2:… $104,785
The Research Foundation For The State University Of New York Specific Aim 1: Optimize a 3-D multisource adaptive current tomography EIT system for the needs and constraints of imaging very young intubated infants. Design,… $154,027
The Regents Of The University Of Colorado The University of Colorado Denver will provide oversight for all study activities including: assisting in identifying and recruiting research subjects,… $58,223
GE Medical Systems Information Technologies, Inc. Task for year 1: 1. Develop electrode solution and perform bench test 2. Support the hardware ACT5 optimization, including 1) cable and connection solution 2)… $226,669
The Research Foundation For The State University Of New York Specific Aim 1: Optimize a 3-D multisource adaptive current tomography EIT system for the needs and constraints of imaging very young intubated infants. Design,… $216,437

Quick answers

Who received award R01HD113290?

R01HD113290 was awarded to Colorado State University by National Institute of Child Health and Human Development (National Institutes of Health) on June 28, 2024.

How much is award R01HD113290 worth?

$1,948,859 has been obligated on R01HD113290.

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