The opioid in pregnancy: imaging of oxygenation, inflammation, and development in brain & placenta project (opioid BPP)
Active Project Grant Awarded Last action
- Award ID
- R01HD113199
- Recipient
-
The Washington University UEI L6NFUM28LQM5
- Awarding agency
-
National Institute of Child Health and Human Development
National Institutes of Health, Department of Health and Human Services
- Obligated
- $3,093,122
Award facts
- Assistance listing
- 93.279 Drug Use and Addiction Research Programs
- Completion date 64% complete
- Originally
- Funding agency
- National Institute on Drug Abuse National Institutes of Health, Department of Health and Human Services
- Place of performance
- St. Louis, MO 63110, USA
Award details come from USAspending.gov.
Description
- Abstract
- Maternal opioid use disorder (OUD) is rapidly increasing in prevalence, and is associated with severe morbidities in offspring, such as neonatal opioid withdrawal syndrome (NOWS), brain dysmaturation, and impaired neurodevelopment (ND). However, little is known regarding the mechanisms by which maternal OUD causes these outcomes, so our ability to mitigate the impact of prenatal opioid exposure (POE) on outcomes is poor. Here, we propose to test the central hypothesis that POE causes abnormal neurodevelopment through direct actions on the fetal brain. Additionally, we propose that POE causes abnormal neurodevelopment via moderation effects from the placenta through mechanisms of hypoxia and inflammation. Strikingly, our preliminary results from the placental pathology of 17 POE pregnancies confirm hypoxic lesions in every patient. Furthermore, our preliminary work using placental immune imaging (PII), an advanced diffusion magnetic resonance imaging (DMRI) technology, confirmed elevated placental inflammation and decreased oxygenation, both near the chorionic plate in a POE 36-week pregnancy compared to unexposed controls. Placental hypoxia and inflammation are two known etiologies that cause fetal WM injury and brain dysmaturation, and our own data show that fetuses with impaired cerebral oxygenation have the greatest reductions in brain volume and WM alterations. Importantly, we have demonstrated that fetal brain volume most consistently predicted 2-year ND (N=78, R=0.32-0.47; all P
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $755,393 | |
| Original award | $2,337,729 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Research Foundation For Mental Hygiene Inc. | $89,009 | |
| The Children's Hospital Corporation | $87,250 | |
| The Children's Hospital Corporation | $0 | |
| Research Foundation For Mental Hygiene Inc. | $265,457 | |
| The Children's Hospital Corporation | $247,891 |
Quick answers
Who received award R01HD113199?
R01HD113199 was awarded to The Washington University by National Institute of Child Health and Human Development (National Institutes of Health) on August 25, 2023.
How much is award R01HD113199 worth?
$3,093,122 has been obligated on R01HD113199.
Which agency awarded R01HD113199?
National Institute of Child Health and Human Development (National Institutes of Health) awarded R01HD113199, with funding from National Institute on Drug Abuse (National Institutes of Health).
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