Dose based aspirin pharmacokinetics and pharmacodynamics in pregnancy and association with pregnancy outcomes
Active Project Grant Awarded Last action
- Award ID
- R01HD112076
- Recipient
-
Thomas Jefferson University UEI R8JEVL4ULGB7
- Awarding agency
-
National Institute of Child Health and Human Development
National Institutes of Health, Department of Health and Human Services
- Obligated
- $1,939,213
Award facts
- Assistance listing
- 93.865 Child Health and Human Development Extramural Research
- Completion date 37% complete
- Place of performance
- Philadelphia, PA 19107, USA
Award details come from USAspending.gov.
Description
- Abstract
- Background: aspirin is recommended in high risk pregnancies to reduce the risk of preeclampsia and preterm birth, but up to 20% will still have these adverse outcomes. Recommendations for aspirin dose range from 75MG-162MG daily. Gaps in knowledge regarding pregnancy specific aspirin pharmacology and relationship between aspirin response and pregnancy outcome limit optimal use of aspirin to prevent adverse perinatal outcomes. Objective: 1) determine platelet inhibition in response to increased dosing of aspirin through gestation and factors impacting aspirin response. 2) determine aspirin population pharmacokinetics (PK) and PK/PD (PHARMACODYNAMIC) relationship through gestation. 3) determine association between aspirin response and perinatal outcomes. Methods: this is a randomized controlled trial of N=300 high risk singleton pregnancies randomized to either 81MG bid or 162MG daily of aspirin, initiated
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $66,336 | |
| Amendment | $597,034 | |
| Amendment | $597,034 | |
| Original award | $678,809 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| University Of Florida | $118,246 |
Quick answers
Who received award R01HD112076?
R01HD112076 was awarded to Thomas Jefferson University by National Institute of Child Health and Human Development (National Institutes of Health) on January 13, 2025.
How much is award R01HD112076 worth?
$1,939,213 has been obligated on R01HD112076.
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