This federal Project Grant award, totaling $1,313,434.00, was issued by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award is focused on unraveling the genomic causes of unsolved leukodystrophy patients through the use of high-fidelity long-read genome sequencing (HiFi-GS) technology. The primary objectives are to first utilize AI/ML-assisted short-read genome sequencing (SRGS) analyses to identify 125 cases of unsolved leukodystrophy, and then explore the utility of HiFi-GS capabilities such as structural variant detection, methylation analysis, and personal haploid assemblies to provide a more comprehensive assessment of genomic features contributing to these rare pediatric neurological disorders. The project will also validate key findings through functional studies using patient-derived induced pluripotent stem cells and zebrafish models. The award period runs from September 20, 2024 to May 31, 2029, and involves sub-awards to the University of Utah and the Research Institute of the McGill University Health Centre to leverage their specialized expertise in leukodystrophy research and advanced genomic analysis techniques.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $0 | 11/25/24 | ||
| Not listed | $656.7k | 9/20/24 | ||
| Not listed | $656.7k | 9/20/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
42370129S | University Of Utah | Project Grant R01HD111570 | $148.2k | 1/2/25 | |
42370129S | The Research Institute Of The Mcgill University Health Centre | Project Grant R01HD111570 | $107.7k | 12/26/24 |