Examining the effects of live telehealth exercise training on cardiometabolic outcomes in wheelchair users

Active Project Grant Awarded Last action

Award ID
R01HD111059
Recipient
Awarding agency
Obligated
$8,688,972

Award facts

Completion date 75% complete
Funding agency
Office of the Director National Institutes of Health, Department of Health and Human Services
Place of performance
Birmingham, AL 35294, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
For the more than 5.5 million people in the U.S. Who use wheelchairs as their primary mode of ambulation, there is a pervasive lack of research on reducing cardiometabolic risk through structured exercise. Confirmatory analyses have revealed that wheelchair users live predominantly sedentary lifestyles and have substantially higher cardiometabolic risk factors compared to the general population. Although few exercise training studies have investigated cardiometabolic risk in certain subgroups with a disability, small sample sizes and homogeneous groups limit the translatability of this knowledge into clinical practice risk reduction strategies for wheelchair users. To address these issues, we propose to use a robust remote training system with built-in videoconferencing and real-time monitoring of vital sign data (e.g., heart rate, respiratory rate). This procedure will allow US to examine the efficacy of an evidence-based movement-to-music (M2M) program adapted for telehealth delivery and cardio emphasis (M2M-C). We are proposing a two-arm randomized controlled trial including 132 wheelchair users with a poor cardiometabolic profile (e.g., elevated triglycerides) recruited through our established network of clinics serving this population. The long-term goal of this proposal is to develop an effective and enjoyable modality for promoting health-enhancing exercise for wheelchair users by confirming exercise dose requirements for this underrepresented group. The primary aim will examine the average treatment effects of a 24-week M2M-C program on core indicators of CMH in wheelchair users with = 2 cardiometabolic risk factors. CMH outcomes will be measured via blood tests (i.e., high sensitivity C-reactive protein, hemoglobin, fasting insulin, triglycerides, and cholesterol) and dexa scan (i.e., body composition) at baseline and after 12 and 24 weeks of synchronous M2M-C training. The secondary aim will explore the beneficial effects of M2M-C on cardiovascular capacity, physical activity, and quality of life. Cardiovascular capacity will be measured via peak oxygen consumption. Physical activity and quality of life will be measured by self-report instruments validated for this population. The tertiary aim 1 is to evaluate the sustained effects of M2M-C (24 to 36 weeks) on physical activity. After M2M participants complete the 24-week program, they will be instructed to perform asynchronous exercise training using guided M2M online videos for an additional 12 weeks. The tertiary aim 2 is to examine the heterogeneity of treatment effect (HTE), which aims to understand whom the intervention is most effective.

Transactions

Action Obligated Date
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Amendment $661,182
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Original award $661,182
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Subawards

Subrecipient Amount Awarded
Lakeshore Foundation Examining the Effects of Live Telehealth Exercise training on Cardiometabolic Outcomes in wheelchair Users $31,644

Quick answers

Who received award R01HD111059?

R01HD111059 was awarded to University Of Alabama At Birmingham by National Institute of Child Health and Human Development (National Institutes of Health) on February 20, 2023.

How much is award R01HD111059 worth?

$8,688,972 has been obligated on R01HD111059.

Which agency awarded R01HD111059?

National Institute of Child Health and Human Development (National Institutes of Health) awarded R01HD111059, with funding from Office of the Director (National Institutes of Health).

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