Sleep, brain development, and behavioral correlates in a longitudinal cohort of children at risk for ASD
Active Project Grant Awarded Last action
- Award ID
- R01HD101578
- Recipient
-
University Of Washington UEI HD1WMN6945W6
- Awarding agency
-
National Institute of Child Health and Human Development
National Institutes of Health, Department of Health and Human Services
- Obligated
- $11,134,031
Award facts
- Assistance listing
- 93.865 Child Health and Human Development Extramural Research
- Completion date 93% complete
- Originally
- Funding
-
- $10,397,910.00 Federal
- $736,121.00 Non-federal
- Place of performance
- Seattle, WA 98195, USA
Award details come from USAspending.gov.
Description
- Abstract
- Children with autism spectrum disorder (ASD) are 2-3 times more likely to suffer from sleep problems than typically developing children. Despite being a high priority population for sleep research, and despite evidence that sleep problems have pervasive negative consequences for health, behavior, mood, and cognition, the increased occurrence and clinical impact of sleep problems in individuals with a family history of ASD is not well understood. This major public health concern is the focus of our application, "sleep, brain development, and behavioral correlates in a longitudinal cohort of children at risk for ASD". Problems with sleep initiation, circadian timing, and inadequate amount of sleep in a high familial risk (HR) cohort of school-age children are hypothesized to be preceded by altered brain and behavioral development in early childhood. This proposal leverages a recently funded longitudinal follow-up of 7-10 year-old HR children and children with low familial risk for ASD (LR) who have had multiple MRI and behavior assessments since infancy through the NIH autism center of excellence infant brain imaging study (ibis). This sample of 300 HR children includes ~100 diagnosed with ASD at 24 months, ~200 without a diagnosis of ASD but with outcomes ranging from typical development to developmental and psychiatric disorders known to occur at high rates in siblings of children with ASD, and 100 LR children currently returning for assessment, including MRI, during school age. A biopsychosocial model of pediatric sleep problems predicts that some combination of biological, environmental, behavioral and psychiatric factors will account for the increased prevalence of sleep problems in ASD, but IT is unknown whether sleep problems are familial, endophenotypic, or disorder-specific in this population. We propose to: (1) characterize circadian disturbances, sleep duration, and other sleep parameters in the home using actigraphy, validated by sleep diary, and through parent report of behavioral and medical sleep problems, (2) examine brain growth trajectories (from infancy) associated with sleep problems in school-age, and (3) examine the longitudinal behavioral and developmental trajectories and concurrent behavior associated with sleep problems in school-age. Increased understanding of the neurobiology and developmental characteristics of sleep problems in ASD has important implications for developing novel, developmentally-sensitive sleep interventions which may help to reduce behavioral and health problems exacerbated by sleep problems and improve outcomes in this vulnerable population.
Transactions
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| Original award | $736,121 | $736,121 |
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Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| University Of North Carolina At Chapel Hill | $65,626 | |
| The Royal Institution For The Advancement Of Learning | $13,932 | |
| The Washington University | $101,337 | |
| University Of Alabama At Birmingham | $19,118 | |
| The Children's Hospital Of Philadelphia | $113,105 | |
| University Of North Carolina At Chapel Hill | $110,987 | |
| University Of Alabama At Birmingham | $15,369 | |
| The Washington University | $92,999 | |
| The Children's Hospital Of Philadelphia | $105,185 | |
| The Royal Institution For The Advancement Of Learning | $12,539 | |
| University Of North Carolina At Chapel Hill | $103,252 |
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Quick answers
Who received award R01HD101578?
R01HD101578 was awarded to University Of Washington by National Institute of Child Health and Human Development (National Institutes of Health) on May 3, 2021.
How much is award R01HD101578 worth?
$11,134,031 has been obligated on R01HD101578: $10,397,910 in federal funding and $736,121 in non-federal funding.
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