Project Grant R01HD058818

The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), awarded a $3,375,359 Project Grant to The Children's Hospital of Philadelphia (CHOP) to conduct research on the impact of cytokine signaling on epithelial reprogramming and barrier dysfunction in eosinophilic esophagitis (EOE). The project aims to examine the specific roles of STAT3 and STAT1 in regulating STAT6-driven epithelial barrier...

This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $151,444 to The Children's Hospital of Philadelphia (CHOP) to study the development of pediatric allergic diseases and create allergy prediction models using electronic health record (EHR) data. The overarching goal is to improve outcomes in pediatric allergy by understanding the heterogeneous "allergic...

This $153,799 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to characterize the molecular pathways responsible for the initiation and persistence of eosinophilic esophagitis (EoE), a highly inflammatory condition of the esophagus. The University of Utah will conduct RNA sequencing of esophageal tissues during food elimination and reintroduction diets to...

This federal Project Grant award of $716,281 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to investigate the mechanisms by which T regulatory cells control allergic skin inflammation in atopic dermatitis. The research aims to use the DOCK8 deficiency model to study the pathways that drive atopic dermatitis independently of skin barrier defects and determine the mechanisms by which...

This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $1,530,922 to the Ann & Robert H Lurie Children's Hospital of Chicago to refine and validate a symptom report-based food allergy prevalence questionnaire for population-based studies. The project aims to develop a bank of survey questions that can accurately and reliably predict IgE-mediated food allergy, and then conduct a...

This $195,696 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will support the development, refinement, and evaluation of the Supportive Training in the Early Presentation of Food Allergens (STEP-FA) intervention. The goal of this 4-year project is to create an adaptive, behavioral intervention to improve caregiver adherence to recommendations for the early introduction of peanut and egg to infants,...

This $612,917 federal Project Grant was awarded on July 23, 2025 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research by Seattle Children's Hospital, doing business as Seattle Children's Research Institute, to investigate the role of the SIGLEC-9 receptor in regulating mast cell function and its potential for therapeutic targeting to treat mast cell-associated disorders such as...

This Project Grant award of $464,615 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports a study to identify facilitators and barriers to pediatric food allergy management among Latino families in Providence, Rhode Island. The study will use a mixed-methods approach, including Geographic Information Systems analysis to evaluate contextual factors associated with food allergy-related emergency department use, as well...

The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $806,466 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH). The 5-year grant, with a start date of August 1, 2025, aims to define the IgG antibody signatures associated with successful peanut oral immunotherapy (OIT) treatment outcomes. The research will characterize the peanut-specific IgG...

This federal Project Grant award of $586,250 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research at the University of Massachusetts Medical School (UMass Medical) to investigate the generation and regulation of TFH13 cells that drive pathogenic IgE in allergic conditions. The overarching goal is to elucidate the pathways leading to TFH13 cell differentiation, which play a critical...