Project Grant R01HD054356

This $355,123 federal Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research to genetically modify the immune system of the African clawed frog (Xenopus tropicalis) to improve its resistance to the deadly chytrid fungus. The goal is to identify how altering the frog's major histocompatibility complex (MHC) genes affects its ability to fight off this pathogen and survive infection. The project includes a sub-award to the University...

This four-year, $1.16 million project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will support the development of functional genomics tools in cactophilic Drosophila at the University of Arizona. Principal Investigator Luis Matzkin and colleagues will build a transgenic toolkit for three cactus-breeding fly species - Drosophila mojavensis, D. arizonae, and D. buzzatii - leveraging recently generated genome assemblies. The toolkit will include attP...

This Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $270,428 to TEO Therapeutics Incorporated to develop and optimize a biomimetic, shell-free quail xenograft assay platform for more efficient preclinical drug testing in oncology research and development. The key objectives are to: 1) refine and test a hardware product line for the xenograft assay by optimizing throughput and evaluating environmentally-friendly...

This three-year, $1 million Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports the development of viral vectors for gene delivery and manipulation in amphibian research. The Trustees of Columbia University will lead efforts to design new viral vectors with host specificity for amphibians. Researchers at Columbia, the Institute of Science and Technology Austria, the University of Utah, and the Scripps Research Institute will collaborate to test...

The National Human Genome Research Institute (NHGRI) has awarded Atlasxomics Inc. a $799,858 Project Grant (CFDA 93.172 - Human Genome Research) to develop a next-generation, user-friendly spatial epigenomics chip that is adaptable to automation workflows. The key objectives of this Phase I SBIR study are to: Improve the ease of use and flexibility of Atlasxomics' existing spatial epigenomics platform, the Deterministic Barcoding in Tissue for Spatial Omics Sequencing (DBiT-seq) system, to...

The National Human Genome Research Institute (NHGRI) awarded a $550,810 Project Grant (CFDA 93.172 - Human Genome Research) to the University of California, Irvine to develop an innovative AI-assisted laser capture microdissection (AI-LCM) approach for spatial transcriptomics. This new method combines microscopy, next-generation sequencing, and laser capture microdissection to enable high-throughput, comprehensive spatial transcriptomics analysis at the single-cell level with genome-wide...

This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $507,000.00 in funding to the University of California, Davis to conduct research on the evolutionary and functional genomics of genetic novelties and expression adaptation in Drosophila. The key objectives of this 5-year project are: 1) to identify transcriptome novelties in Drosophila melanogaster reproductive...

This Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $194,375 to the University of Wisconsin - Madison to develop robust genome editing tools for generating floxed alleles and editing amino acid changes in zebrafish. The key products and services to be delivered include: Establishing a synthetic exon-mediated integration approach to reliably generate floxed alleles in zebrafish within a single generation, enabling...

This Project Grant award from the Office of the Director at the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $241,500 to the University of California, Davis to develop genomic and transcriptomic resources, transgenesis and gene knockdown tools, and CRISPR gene editing capabilities for the Hydra oligactis species of freshwater cnidarian. The goal is to enable comparative studies between the well-characterized H. vulgaris model and the...

This Project Grant award from the National Human Genome Research Institute (NHGRI), under the Human Genome Research program (CFDA 93.172), will support research at the University of California, San Diego (UC San Diego) to understand the genetic basis of neural cell type evolution in insect retinas. The $328,117 award, effective from September 1, 2024 to June 30, 2028, will enable UC San Diego researchers to use new genomic and genetic tools, such as single-cell sequencing and CRISPR/Cas9...