Project Grant R01EY039476
- The National Eye Institute awarded $753,787 to The General Hospital Corporation (doing business as Massachusetts General Hospital) on August 1, 2026, under the Vision Research program (CFDA 93.867) to develop low-cost ultra-widefield retinal optical coherence tomography (OCT) technology based on photonic-electronic integration. The project addresses cost barriers that limit clinical availability of OCT instrumentation used to detect and monitor diabetic retinopathy, age-related macular...
- The National Eye Institute awarded The Schepens Eye Research Institute $858,394 on August 1, 2026, under the Vision Research program (CFDA 93.867) to develop multimodal foundation models for eye disease screening and prognosis. The research develops a vision-language foundation model trained on pairs of retinal images and clinical notes to enable downstream supervised models for detection and progression prediction of age-related macular degeneration, diabetic retinopathy, and glaucoma. The...
- The National Eye Institute awarded Oregon Health & Science University $498,180 on September 1, 2026, under the Vision Research program (CFDA 93.867) to develop and apply novel optical coherence tomography (OCT) methods for detecting and monitoring photoreceptor changes associated with age-related macular degeneration. The project runs through August 31, 2030, with performance based in Portland, Oregon. Aim 1 investigates cone photoreceptor function impairments in AMD through advancement of...
- The National Eye Institute awarded Oregon Health & Science University $237,341 on August 1, 2026, to develop curvature and color correction techniques for ultrawidefield optical coherence tomography imaging of the retina under the Vision Research program (CFDA 93.867). The project addresses fundamental limitations in current OCT technology by applying GPU-accelerated ray tracing for geometric reconstruction of the retina to eliminate distortion and curvature artifacts in widefield imaging,...
- The National Institutes of Health Office of the Director awarded Oregon Health & Science University $455,322 on September 15, 2025, under the Trans-NIH Research Support program (CFDA 93.310) to develop software tools for creating standardized multimodal electronic health record datasets in ophthalmology research using artificial intelligence. The project will develop AI-driven tools, including natural language processing and large language models, to integrate and standardize multimodal...
- Federal Project Grant Award Summary Kineolabs, Inc. received a $300,001 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) to develop a portable, low-cost line-scan swept-source optical coherence tomography imaging system (LS-SS-OCT). The system is designed for early detection and monitoring of age-related macular degeneration (AMD), diabetic retinopathy, and other eye diseases. The one-year project, which commenced July 1, 2025 and concludes June...
- The National Eye Institute awarded the University of California, Los Angeles $722,904 on May 1, 2026, under the Vision Research program (CFDA 93.867) to conduct secondary analysis of optical coherence tomography (OCT) imaging and clinical data from four NEI-funded uveitis randomized clinical trials, investigating OCT biomarkers—including ellipsoid zone integrity, photoreceptor layer thickness, intraretinal hyperreflective foci, choroidal thickness, and disorganization of retinal inner...
- The National Eye Institute awarded the University of Rochester $684,914 on July 1, 2026, under the Vision Research program (CFDA 93.867) to develop human induced pluripotent stem cell (hiPSC)-derived retinal tissue models for disease research and cell-based therapeutic applications. The award funds two complementary aims. Aim 1 develops a microphysiological model of comprehensive hiPSC-derived retina that emulates the physiological spherical geometry of the human retina in vivo, suitable for...
- The National Eye Institute, National Institutes of Health, awarded $1.234892 million to Intelon Optics, Inc. on September 15, 2025, under the Vision Research program (CFDA 93.867) to develop a next-generation Brillouin Optical Scanner System (BOSS) with improved speed, accuracy, and sensitivity for ocular biomechanics measurement. The project will translate research technology developed by Dr. Scarcelli at the University of Maryland into a commercially viable clinical device capable of detecting...
- The National Eye Institute of the Department of Health and Human Services awarded $571,206 to the University of Maryland, Baltimore on May 1, 2026, under the Vision Research program (CFDA 93.867) to develop, refine, and validate sensitive and robust adaptive optics-optical coherence tomography (AO-OCT) biomarkers for glaucoma detection and progression monitoring. The project addresses the need for earlier detection of glaucoma progression and mechanistically relevant biomarkers to support...
The National Eye Institute awarded The Schepens Eye Research Institute Inc. $506,030 on September 1, 2026, under the Vision Research program (CFDA 93.867) to develop an open-source solution for exporting and integrating optical coherence tomography data across institutions. The project addresses a critical barrier in ophthalmic research: OCT imaging data from multiple manufacturers is stored in over ten proprietary, undocumented formats with export tools that are prohibitively slow—exporting a full institutional dataset could require an estimated 11 years. The funded work will unlock this data for large-scale research and AI applications by delivering three integrated components. Aim 1 establishes a unified, open OCT data format with dual implementations: a DICOM version for clinical IT system integration and an HDF5 version optimized for machine learning performance, supported by high-performance Rust-based converters translating all major vendor formats. Aim 2 delivers turnkey repository software automating data extraction from picture archiving and communication systems or devices, supporting flexible de-identification, and providing researcher-friendly programming interfaces in C, Python, and R. Aim 3 deploys this infrastructure across 17 U.S. institutions. Performance occurs in Boston, Massachusetts, with an ultimate completion date of April 30, 2031. The work builds on the team's prior leadership of the IRIS and SOURCE registries, which together cover over 70 million patients but have lacked OCT imaging access due to these technical barriers.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $506.0k | 9/2/26 |