Project Grant R01EY039375
- The National Eye Institute awarded Oregon Health & Science University $498,180 on September 1, 2026, under the Vision Research program (CFDA 93.867) to develop and apply novel optical coherence tomography (OCT) methods for detecting and monitoring photoreceptor changes associated with age-related macular degeneration. The project runs through August 31, 2030, with performance based in Portland, Oregon. Aim 1 investigates cone photoreceptor function impairments in AMD through advancement of...
- The National Eye Institute awarded Baylor College of Medicine $100,228 on March 22, 2027, under the Vision Research program (CFDA 93.867) to validate endothelial mediators in glaucoma neurovascular dysfunction using ligandomics technology. The recipient will independently validate the binding selectivity of glaucoma-associated endothelial ligands to ocular hypertensive versus healthy retinal vessels and verify their functional roles in retinal ganglion cell loss and neurovascular dysfunction...
- Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded $417,162 to the University of Houston System for a two-year project (July 1, 2025 – June 30, 2027) investigating the birefringence properties of the lamina cribrosa and posterior eye structures as they relate to glaucoma detection and diagnosis. The project addresses a critical clinical need by developing advanced optical imaging methodologies to detect early structural and stress-related changes...
- The National Eye Institute awarded Emory University $126,530 in project grant funding on August 1, 2026, under the Vision Research program (CFDA 93.867) to investigate the role of ezrin in Schlemm's canal cell mechanobiology in primary open-angle glaucoma. The research addresses how mechanical forces regulate transcellular pore (i-pore) formation in the Schlemm's canal inner wall, a key determinant of aqueous humor outflow and intraocular pressure. Ezrin, a mechano-responsive protein linking...
- The National Institutes of Health National Eye Institute awarded the University of Pittsburgh $403,633 on September 1, 2026, under the Vision Research program (CFDA 93.867) to develop a portable trans-palpebral tonometer (PT-2) for self-administered intraocular pressure measurement in glaucoma diagnosis and management. The research aims to advance a hand-held device based on solitary wave propagation technology that enables patients to self-administer IOP measurements at home without...
- The National Eye Institute awarded Oregon Health & Science University $237,341 on August 1, 2026, to develop curvature and color correction techniques for ultrawidefield optical coherence tomography imaging of the retina under the Vision Research program (CFDA 93.867). The project addresses fundamental limitations in current OCT technology by applying GPU-accelerated ray tracing for geometric reconstruction of the retina to eliminate distortion and curvature artifacts in widefield imaging,...
- The National Eye Institute awarded Oregon Health & Science University $264,435 on May 1, 2026, under the Vision Research program (CFDA 93.867) to define the pathophysiology of microcephaly and chorioretinopathy (MCCRP) associated with defects in the gamma-tubulin ring complex. The project will use conditional knockout mouse models and tamoxifen-inducible endothelial cell-specific Cre recombinase to test the hypothesis that tubgcp4 and tubgcp6 serve critical roles in retinal and brain...
- The National Eye Institute awarded The Trustees of Columbia University in the City of New York $532,079 on September 1, 2026, under the Vision Research program (CFDA 93.867) to characterize the role of apelin signaling in Schlemm's canal development and its relationship to early-onset glaucoma. The research employs mouse models to express and trace the apelin receptor during Schlemm's canal development, uses conditional and inducible mouse models to study loss of apelin receptor function...
- The National Eye Institute awarded The Schepens Eye Research Institute $858,394 on August 1, 2026, under the Vision Research program (CFDA 93.867) to develop multimodal foundation models for eye disease screening and prognosis. The research develops a vision-language foundation model trained on pairs of retinal images and clinical notes to enable downstream supervised models for detection and progression prediction of age-related macular degeneration, diabetic retinopathy, and glaucoma. The...
- The National Eye Institute awarded the University of Alabama at Birmingham $636,862 on April 1, 2026, under the Vision Research program (CFDA 93.867) to develop and validate mechanical, vascular, and morphometric biomarkers of eye-specific susceptibility to glaucoma onset and progression. The recipient will perform longitudinal optical coherence tomography imaging to quantify optic nerve head mechanical deformations and vascular perfusion in vivo in an animal model of unilateral glaucoma...
The National Eye Institute awarded Legacy Emanuel Hospital & Health Center $702,487 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate pulsatility in retinal and optic nerve head blood flow in glaucomatous disease. The research develops diagnostic tools using scanning laser ophthalmoscopy and laser speckle flowgraphy to measure changes in vessel diameter and blood flow across the cardiac pulse cycle. The project tests two competing hypotheses: whether elevated pulsatility results from biomechanical stiffening of vessels induced by elevated intraocular pressure, or from transient vasoconstriction due to aberrant pericytes and upregulated endothelin receptors. Specific Aim 1 will create mechanical strain maps and compare them against flow pulsatility, disease stage, and progression rate. Specific Aim 2 will quantify blood flow changes in response to suspected vasoconstriction. Work is performed in Portland, Oregon, with a period of performance through April 30, 2030. The research supports NEI's mission to drive innovative research to understand vision diseases and prevent blindness, with the ultimate goal of developing potential new diagnostic tests for clinical use in glaucoma management.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $702.5k | 8/19/26 |