Project Grant R01EY038837
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded $624,743 to the Regents of the University of California, doing business as University of California, Berkeley, on May 1, 2026, under the Vision Research program (CFDA 93.867). The award funds research into the function and regulation of constitutive prostaglandin D2 and DP receptor signaling in retinal health and neurodegeneration. The research investigates the physiological and...
- The National Eye Institute (NEI) awarded $764,881 to the University of Colorado-Denver under the Vision Research program (CFDA 93.867) on September 15, 2025, to support a two-year research project investigating the role of advanced glycation end products (AGEs) in primary open-angle glaucoma (POAG). The project will generate fundamental research findings and preclinical data on how AGEs accumulate in trabecular meshwork (TM) tissues and contribute to elevated intraocular pressure and optic nerve...
- The National Eye Institute awarded The Trustees of Columbia University in the City of New York $532,079 on September 1, 2026, under the Vision Research program (CFDA 93.867) to characterize the role of apelin signaling in Schlemm's canal development and its relationship to early-onset glaucoma. The research employs mouse models to express and trace the apelin receptor during Schlemm's canal development, uses conditional and inducible mouse models to study loss of apelin receptor function...
- The National Eye Institute awarded The Johns Hopkins University $624,689 under the Vision Research program (CFDA 93.867) on September 1, 2026, to develop machine learning-driven peptide engineering for sustained intraocular pressure lowering in glaucoma treatment. The research applies artificial intelligence methodology adapted from the super learning approach to engineer multifunctional peptides that bind to melanin, enter cells efficiently, and exhibit low cytotoxicity. High-throughput...
- The National Eye Institute awarded Baylor College of Medicine $100,228 on March 22, 2027, under the Vision Research program (CFDA 93.867) to validate endothelial mediators in glaucoma neurovascular dysfunction using ligandomics technology. The recipient will independently validate the binding selectivity of glaucoma-associated endothelial ligands to ocular hypertensive versus healthy retinal vessels and verify their functional roles in retinal ganglion cell loss and neurovascular dysfunction...
- The National Eye Institute of the Department of Health and Human Services awarded $571,206 to the University of Maryland, Baltimore on May 1, 2026, under the Vision Research program (CFDA 93.867) to develop, refine, and validate sensitive and robust adaptive optics-optical coherence tomography (AO-OCT) biomarkers for glaucoma detection and progression monitoring. The project addresses the need for earlier detection of glaucoma progression and mechanistically relevant biomarkers to support...
- The National Eye Institute awarded The Schepens Eye Research Institute $545,948 on April 1, 2026, under the Vision Research program (CFDA 93.867) to support Project Grant R01EY037230, "Understanding the Role of Reactive Astrocytes in Glaucoma." The award funds research into how astrocytes—the primary cellular component of the optic nerve head—become reactive in glaucoma and alter their support of retinal ganglion cells. The project investigates metabolic changes in astrocytes exposed...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded The Leland Stanford Junior University $2.085 million under the Vision Research program (CFDA 93.867) on September 30, 2025, to investigate cholinergic dysfunction in glaucoma using advanced magnetic resonance imaging and spectroscopy techniques. The research tests the hypothesis that glaucoma is driven by impairments of the visual pathways mediated by the cholinergic nervous...
- The National Eye Institute, part of the National Institutes of Health, awarded the University of New Mexico Health Sciences Center $350,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate neutrophil extracellular traps and chemokine signaling in blood-retinal barrier disruption in diabetic retinopathy. The funded research targets mechanisms underlying diabetic retinopathy, the leading cause of vision loss in middle-aged adults....
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded $693,423 to the University of Mississippi Medical Center on September 15, 2025, under the Vision Research program (CFDA 93.867) to develop and test a multivalent antibody cocktail for treating and preventing bacterial endophthalmitis. The funded research combines eight antibodies targeting virulence factors of Staphylococcus epidermidis, Staphylococcus aureus, and...
The National Eye Institute, part of the National Institutes of Health within the Department of Health and Human Services, awarded Creighton University $350,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support discovery and development of novel trifunctional hybrid compounds for glaucoma therapy. The funded research focuses on designing and evaluating trifunctional hybrid compounds that integrate three disease-modifying entities—an FP receptor agonist, a nitric oxide donor, and a hydrogen sulfide releasing moiety—to simultaneously address elevated intraocular pressure and glaucomatous neurodegeneration. The work builds on a lead molecule, AMP249, with particular emphasis on a derivative compound, JDB023, which demonstrated sustained release of nitric oxide and hydrogen sulfide in vitro (exceeding 15 days), superior intraocular pressure-lowering activity in vivo, and neuroprotection in ex vivo models. The research employs structure-activity relationship approaches to optimize compound stability and efficacy, with proposed mechanisms involving FP receptor activation and modulation of cGMP and KAtp signaling pathways to drive extracellular matrix remodeling and reduce oxidative stress. Performance occurs in Omaha, Nebraska. The award runs from September 1, 2026, through July 31, 2031. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $350.0k | 8/21/26 |