Project Grant R01EY037700
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded the Board of Regents of the University of Nebraska (University of Nebraska Medical Center) $1,267,127 on August 1, 2026 for Project Grant R01EY038077, funded under the Vision Research program (CFDA 93.867). The award funds clinical and molecular biomarker surveillance of mpox-related ocular disease. The research characterizes the spectrum of ophthalmic manifestations of mpox...
- The National Eye Institute, part of the National Institutes of Health within the Department of Health and Human Services, awarded Creighton University $350,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support discovery and development of novel trifunctional hybrid compounds for glaucoma therapy. The funded research focuses on designing and evaluating trifunctional hybrid compounds that integrate three disease-modifying entities—an FP...
- The National Eye Institute, part of the National Institutes of Health, awarded the University of New Mexico Health Sciences Center $350,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate neutrophil extracellular traps and chemokine signaling in blood-retinal barrier disruption in diabetic retinopathy. The funded research targets mechanisms underlying diabetic retinopathy, the leading cause of vision loss in middle-aged adults....
- The National Eye Institute awarded The University of Chicago $582,115 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate the role of lens connexins, cellular stress, and ionic imbalance in cataract formation. The research will define pathogenic mechanisms linking disruption of lens ionic homeostasis and formation of calcium-containing deposits to cataract development. The project utilizes human lens material, mutant mouse models, and in vitro systems to...
- The National Eye Institute, a bureau of the Department of Health and Human Services National Institutes of Health, awarded $497,740 to the University of Illinois on April 1, 2026, under the Vision Research program (CFDA 93.867) to fund research into neuro-epithelial interactions in corneal disease and repair, with Principal Investigator Elmira Jalilian. The project investigates how corneal epithelial cells and trigeminal nerve fibers (the V1 ophthalmic branch) interact to maintain corneal...
- The National Eye Institute awarded the University of Mississippi Medical Center $584,806 on August 1, 2026, under the Vision Research program (CFDA 93.867) to investigate mechanisms of adhesion and colonization during pneumococcal keratitis caused by Streptococcus pneumoniae. The research examines how pneumococcal bacteria regulate their outer polysaccharide capsule to adhere and colonize the corneal surface, and identifies a master regulatory system that controls bacterial survival and...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded $693,423 to the University of Mississippi Medical Center on September 15, 2025, under the Vision Research program (CFDA 93.867) to develop and test a multivalent antibody cocktail for treating and preventing bacterial endophthalmitis. The funded research combines eight antibodies targeting virulence factors of Staphylococcus epidermidis, Staphylococcus aureus, and...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded $628,100 to the University of Miami on May 1, 2026, under the Vision Research program (CFDA 93.867) to advance understanding of lens remodeling in childhood myopia development and progression. The project will develop new technologies to measure three-dimensional lens shape, ocular biometry, central and peripheral refraction, and accommodation-related changes in children. The...
- The National Eye Institute awarded N'waii Inc. $697,600 on September 30, 2025, under the Vision Research program (CFDA 93.867) to develop first-in-class mitochondrially targeted antioxidants for dry eye disease treatment. Work will be performed in Chicago, Illinois, with a completion date of September 29, 2027. The project focuses on a proprietary small-molecule lead candidate designed to address oxidative stress and mitochondrial dysfunction underlying meibomian gland dysfunction, a predominant...
- The National Eye Institute awarded the Regents of the University of Michigan $519,644 on August 1, 2026, under the Vision Research program (CFDA 93.867) to investigate the metabolic and molecular mechanisms by which glutamine promotes photoreceptor health and survival. The research addresses photoreceptor death as a cause of vision loss in retinal diseases. The recipient's work defines the downstream metabolic and molecular pathways by which glutamine catabolism impacts rod photoreceptor health,...
The National Eye Institute awarded the Board of Regents of the University of Nebraska, through its University of Nebraska Medical Center division, $383,750 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate oxidative stress and NLRP3 inflammasome activation in eye lens pathobiology during aging. The research examines molecular pathways linking reactive oxygen species amplification, dysregulation of antioxidant defenses, and inflammasome-driven inflammatory responses to age-related blinding disorders. The project uses lens epithelial cells as a model system to explore how increased transcription factor KLF9 expression suppresses antioxidant genes and triggers ROS amplification and cell damage in aging lenses, and how this adverse signaling leads to aberrant TXNIP expression and NLRP3 inflammasome activation. The research tests whether antioxidant interventions such as PRDX6 can reverse these pathological cascades. Performance occurs in Omaha, Nebraska, with a period of performance extending through March 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $383.8k | 8/31/26 |