Project Grant R01EY037542
- This $440,806 Project Grant awarded by the National Eye Institute (CFDA 93.867 - Vision Research) will fund research to define the role of the molecular chaperone protein P58IPK in retinal neurons during the pathogenesis of diabetic retinopathy. The research aims to investigate new molecular pathways by which P58IPK regulates protein and lipid homeostasis through the integrated stress response and lipid glycosylation processes, and evaluate the neuroprotective effects of targeting P58IPK and its...
- The National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), awarded a $144,200 Project Grant to Pennsylvania State University's Milton S. Hershey Medical Center. The grant, effective June 1, 2025 through November 30, 2027, will fund research to characterize the molecular mechanisms underlying increased levels of the protein REDD1 in the retina due to diabetes, and explore alternative intervention strategies for preventing retinal complications caused by...
- This Project Grant award from the National Eye Institute (NEI), part of the U.S. Department of Health and Human Services, aims to advance understanding of the molecular and cellular mechanisms underlying diabetic retinopathy (DR) and diabetic macular edema (DME). The $1,786,652 award, granted on September 15, 2025, supports the application of the "TEMPO" proteomic platform to identify protein biomarker signatures and key cellular drivers of DR stages and DME using human liquid biopsy...
- This federal Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) provides $144,362 to support research on the role of hyperglycemia and hyperinsulinemia in the breakdown of the blood-retinal barrier in diabetic retinopathy. The project aims to identify the spatial localization and functions of claudins, key tight junction proteins, in the retinal pigment epithelium (RPE) and test the hypothesis that regulation of RPE claudins by hyperglycemic...
- This $403,750 Project Grant from the National Eye Institute of the Department of Health and Human Services will fund research into the regulation of retinal microvascular stiffness by the matricellular protein CCN1 and its implications for ischemic retinopathy. The awardee, the Research Foundation for the State University of New York on behalf of SUNY Downstate Health Sciences University, will investigate the effects of CCN1 on the mechanical properties of retinal microvascular endothelial cells...
- This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) supports the development of a novel, noninvasive, and sensitive diagnostic method to measure retinal dysfunction. The $491,466 award will fund research at the University of California, San Francisco (UCSF) from January 1, 2025 to December 31, 2026. The project aims to create a scalable diagnostic tool that can detect the earliest signs of retinal diseases like diabetic retinopathy and retinitis pigmentosa,...
- The University of Southern California (USC) received a $480,140 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) to develop new treatment strategies for diabetic retinopathy (DR). The key objectives are to: 1) evaluate the targeted delivery of therapeutic extracellular vesicles (exosomes) to areas of retinal vascular dysfunction in DR, and 2) determine if Müller glia-derived exosomes can protect the retinal neurovascular unit and mitigate DR...
- This federal Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $155,000 in funding to The Johns Hopkins University for a research project titled "Diabetic Retinal Neurodegeneration in Youth Onset Diabetes". The project aims to describe retinal neurodegeneration in youth with type 1 and type 2 diabetes, as well as prediabetes, using optical coherence tomography (OCT) imaging. It will analyze a well-characterized cohort of 380 youth with...
- The National Eye Institute (NEI), under the Department of Health and Human Services, awarded a $358,065 Project Grant to Revel Pharmaceuticals Inc., a biotechnology company in San Francisco, California. The grant is part of the NEI's Vision Research program (CFDA 93.867), which supports research to understand, prevent, and treat vision-related conditions and diseases. The goal of this Phase I grant is for Revel Pharmaceuticals to optimize lead drug candidates and demonstrate the activity of...
- The National Eye Institute (NEI), part of the National Institutes of Health, awarded a $331,131 Project Grant under the Vision Research program (CFDA 93.867) to Physical Sciences Inc. (PSI) to develop and validate a high-resolution retinal imaging system with light flicker capabilities. This system aims to enable objective characterization of the photoreceptor response to light and quantify differences between normal and diseased eyes, particularly for patients with diabetic retinopathy. PSI,...
This federal Project Grant award of $1,523,433.00 from the National Eye Institute (CFDA 93.867 - Vision Research) supports research by the Doheny Eye Institute in Pasadena, California to investigate the mechanobiology of retinal vascular inflammation and degeneration in diabetic retinopathy. The key products and services to be delivered include: Exploring how diabetes-induced stiffening of the retinal capillary basement membrane leads to activation of endothelial cells and inflammation, ultimately causing vascular degeneration. The research aims to determine the role of the mechanosensitive ion channel TRPV4 in this process and evaluate whether pharmacological activation of TRPV4 can block retinal endothelial cell activation in diabetic mice. This work may lead to the development of new therapeutic approaches for treating early-stage diabetic retinopathy. The Doheny Eye Institute, a non-profit ophthalmology research organization, will conduct this 3-year research project from September 1, 2025 through August 31, 2028. The award provides funding for the institute's investigations into the mechanical determinants of retinal vascular inflammation and degeneration in diabetes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.5m | 8/29/25 |