Project Grant R01EY036865
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded The Schepens Eye Research Institute, Inc. a Project Grant of $545,948 under the Vision Research program (CFDA 93.867) to advance understanding of glaucoma pathophysiology. The award, effective April 1, 2026 through March 31, 2030, supports research investigating the role of reactive astrocytes in glaucoma progression and retinal ganglion cell (RGC) survival. The research aims to move beyond traditional neurocentric...
- Federal Project Grant Award Summary The National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) awarded $902,000 to the University of California, San Francisco for a two-year project (September 1, 2025 – August 31, 2027) to conduct multimodal characterization of a novel inherited mouse model of glaucoma. The primary deliverables include comprehensive phenotypic characterization of GLIS1 knockout mice across two genetic backgrounds, evaluating structural and functional...
- Summary of Federal Project Grant Award The National Eye Institute (NEI) awarded a $422,125 Project Grant to the University of Miami's Office of Research Administration—School of Medicine on August 1, 2025, under the Vision Research program (CFDA 93.867) for a two-year project period concluding July 31, 2027. This award funds research investigating cholesterol homeostasis as a therapeutic target for demyelinating eye diseases, which are pathologies affecting the optic nerve that can cause...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded $427,625 under the Vision Research program (CFDA 93.867) to The Washington University for a two-year project (April 1, 2026 – March 31, 2028) to develop novel statistical methodologies for detecting and characterizing visual field progression in primary open-angle glaucoma (POAG). The primary deliverables include: (1) a change-point statistical model integrating longitudinal mean deviation measures to identify early disease...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded UC Berkeley a $481,500 Project Grant under the Vision Research program (CFDA 93.867) effective September 1, 2025 through August 31, 2026. The grant funds fundamental research investigating the role of retinal waves in vascular development, specifically examining neural-glial-vascular signaling mechanisms that regulate blood vessel formation in the developing retina. This research directly addresses clinical applications for...
- Federal Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded Northwestern University a $1.62 million Project Grant on September 1, 2025, to develop computational models and diagnostic tools for improving glaucoma treatment outcomes. The three-year project, extending through August 31, 2028, focuses on modeling aqueous humor outflow based on a digital twin of the anterior eye imaged by robotic optical coherence tomography (OCT). The...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded $255,722 under the Vision Research program (CFDA 93.867) to the University of California, Berkeley, effective September 15, 2025, through August 31, 2027. This Project Grant supports fundamental research investigating the role and regulation of optic nerve microglia in glaucomatous neuropathy. The research deliverables include scientific findings on how lipoxin B4 (LXB4), an endogenous lipoxin produced by retinal...
- Federal Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded a $764,881 Project Grant to the University of Colorado-Denver on September 15, 2025, to investigate the role of advanced glycation end products (AGEs) in primary open angle glaucoma (POAG). Primary open angle glaucoma is the most common form of glaucoma, accounting for approximately 80% of all glaucoma cases globally and affecting 80 million people, with 11 million...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded The Aird $610,000 under the Vision Research program (CFDA 93.867) on September 1, 2025, for a 12-month project period concluding August 31, 2026. This Project Grant supports the development and commercialization of an adaptive optics optical coherence tomography (AO-OCT) system designed to provide high-resolution, wide-field retinal imaging in small animal models, particularly mice. The primary deliverables include a portable...
- Federal Grant Award Summary Vanderbilt University Medical Center received a $481,250 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective June 1, 2025 through May 31, 2027. The award funds research investigating the molecular mechanisms by which mutations in the ADAMTS10 gene contribute to primary open-angle glaucoma (POAG), a leading cause of irreversible blindness. The research employs genetically modified mouse models carrying...
The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded a three-year Project Grant totaling $2,674,763 to Centre Hospitalier De L'Université De Montréal (CHUM) beginning September 30, 2025, with completion targeted for September 29, 2028. This award funds research investigating interpericyte tunneling nanotubes (IPTNTs) as therapeutic targets for glaucoma treatment and vision restoration. The research will generate empirical findings on the mechanisms underlying glaucoma-induced vascular deficits and will develop molecular targets for protecting or regenerating IPTNTs to improve blood supply to the retina and optic nerve. The primary deliverables include identification of key molecular mechanisms disrupting IPTNT-mediated blood flow regulation through three specific research aims: determining the role of glia-derived S100B protein in IPTNT damage, evaluating dysregulated adenosine signaling effects on capillary dynamics, and establishing the efficacy of platelet-derived growth factor BB as an IPTNT regeneration strategy. Additionally, the project will produce an innovative live imaging platform applicable to broader research contexts, enabling enhanced understanding of how vascular defects affect retinal ganglion cell function during glaucomatous stress. The research utilizes established glaucoma models in mice and non-human primates combined with cellular, genetic, molecular, and advanced imaging technologies to deliver clinically relevant endpoints.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.7m | 9/26/25 |