This $201,825 Project Grant award from the National Eye Institute (NEI) Vision Research program (CFDA 93.867) supports research to evaluate the use of condensin inhibitors as a potential topical treatment for Pseudomonas aeruginosa bacterial eye infections. The lead investigator, Dr. Valentin Rybenkov at the University of Oklahoma, will collaborate with Dr. Michelle Callegan at the University of Oklahoma Health Sciences Center to conduct in vivo studies examining the toxicity, corneal...
The National Eye Institute (NEI) awarded a $586,258 Project Grant under the Vision Research program (CFDA 93.867) to Wayne State University to conduct research on the role of eosinophils in modulating the corneal response to Pseudomonas aeruginosa infection. The research, spanning from Jul 1, 2025 to Apr 30, 2029, aims to characterize the spatiotemporal distribution, phenotypic profiles, and proteomic changes of eosinophils during corneal inflammation and infection using mouse models. The...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), aims to develop a rapid, culture-independent diagnostic approach for detecting pathogens and antimicrobial resistance in sight-threatening ocular infections. The $425,000 award, effective August 1, 2024 through July 31, 2029, will support the Massachusetts Eye and Ear Infirmary in creating a metagenomic sequencing-based platform that uses portable nanopore sequencers to provide...
The National Eye Institute (NEI) awarded a $1,083,078 Project Grant under the Vision Research federal grant program (CFDA 93.867) to the University of California, Irvine (UCI) to conduct research on the role of monocytes and neutrophils in fungal keratitis. The project aims to examine neutrophil activation and the effect of monocyte depletion on neutrophil function in infected corneas, investigate the role of ICAM-1+ neutrophils and the HV1 proton channel in fungal keratitis, and explore the...
The National Eye Institute (NEI) awarded a $974,348 Project Grant under the Vision Research program (CFDA 93.867) to Wayne State University to conduct research on metabolic signatures in the vitreous of patients with bacterial and fungal endophthalmitis. The research aims to identify potential biomarkers for diagnosing endophthalmitis and guiding appropriate antimicrobial therapy. Specifically, the project will perform untargeted metabolomics analysis on vitreous samples from culture-positive...
The National Eye Institute (NEI), under the Department of Health and Human Services, awarded a $440,806 Project Grant (CFDA 93.867 - Vision Research) to The Research Foundation for the State University of New York (RF SUNY) to study the role of the molecular chaperone p58IPK in retinal neurons under diabetic conditions. The goal is to define the in vivo function of p58IPK in regulating protein and lipid homeostasis through the integrated stress response and lipid glycosylation pathways, and to...
The National Eye Institute (NEI) awarded a $192,500 Project Grant under the Vision Research program (CFDA 93.867) to Wayne State University to conduct research on the impact of acute and chronic opioid exposure on ocular innate immunity and infections. The goal is to evaluate how repeated opioid exposure, such as from morphine and fentanyl, impairs both systemic and ocular innate immunity, leading to increased incidence and severity of infectious endophthalmitis, a blinding eye infection. The...
This $185,000 Project Grant award from the National Eye Institute (NEI) under CFDA 93.867 (Vision Research) supports research to discover novel disease-modifying therapies for the prevention and treatment of glaucoma. The primary awardee, the University of North Texas Health Science Center at Fort Worth, will employ computational pharmacology approaches to identify small molecule inhibitors that can interfere with the GREM1-BMP protein-protein interaction, a key pathogenic mechanism contributing...
The National Eye Institute (NEI) awarded a Project Grant (CFDA 93.867 - Vision Research) in the amount of $753,189 to Trustees of Boston University, doing business as Boston University Medical Campus, with a period of performance from August 1, 2024 to May 31, 2029. The grant will support research to identify novel therapeutic targets for corneal epithelial defects by revealing the differential roles of basal epithelial cells in the central cornea, limbus, and conjunctiva in corneal health and...
This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides $246,000 to The Regents of the University of California, San Francisco (UCSF) to leverage programmable phage display peptidomes and high-throughput sequencing to identify autoantigens and antibodies important for uveitis, an ocular inflammatory disease. The two-year project aims to use comprehensive human and viral peptidome phage libraries to bio-pan for autoantigens...