Investigating the effect of arousal on visual processing
Active Project Grant Awarded Last action
- Award ID
- R01EY035640
- Recipient
-
Trustees Of Boston University UEI THL6A6JLE1S7
- Awarding agency
-
National Eye Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $870,720
Award facts
- Assistance listing
- 93.867 Vision Research
- Completion date 42% complete
- Place of performance
- Boston, MA 02215, USA
Award details come from USAspending.gov.
Description
- Abstract
- How do states of arousal affect how we process visual information? Whether driven by a momentary startle response or by lower-frequency fluctuations in mood or energization, arousal states play a key regulatory role in our daily lives and exert widespread modulatory effects on neural information processing. Despite the ubiquitous role that arousal levels likely play in modulating cognition, the precise mechanisms by which arousal state alters neural representations remain unclear. One of the prevailing theories for arousal posits that the locus-coeruleus norepinephrine system alters representations by modulating the input-output gain of neural systems. The visual system serves as an ideal test bed for testing this theory, as decades of vision science has provided a deep understanding of the mechanisms that locally regulate the gain of response in early visual cortex. Furthermore, well-validated measurement methods are available for quantifying response properties of vision-related neural systems noninvasively in humans. In the proposed project, we leverage our knowledge of the neural computations within the visual system to directly test the hypothesis that emotional arousal alters representations via changes in the gain of representation. To do so, the proposed project will use a combination of state-of-the- art functional neuroimaging methods paired with psychophysics to examine the influence of arousal on fundamental properties of the human visual system: orientation, spatial frequency and contrast processing. Taken together, these visual features play a substantial role in determining our ability to visually represent and interact with the environment; any changes in these responses with arousal would have potentially substantial impact on what we can and cannot see at any given moment. By revealing the manner in which visual representations vary with arousal levels, our results will not only provide constraints for computational models of vision and arousal, but also have the potential to establish a theoretical and empirical framework for testing models of arousal that could eventually generalize to other systems.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | -$119,057 | |
| Amendment | $119,057 | |
| Amendment | $119,057 | |
| Amendment | $194,110 | |
| Amendment | $194,110 | |
| Original award | $363,443 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Stichting Radboud Universiteit | $119,057 |
Quick answers
Who received award R01EY035640?
R01EY035640 was awarded to Trustees Of Boston University by National Eye Institute (National Institutes of Health) on September 30, 2024.
How much is award R01EY035640 worth?
$870,720 has been obligated on R01EY035640.
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