Interocular suppression and selective attention in amblyopia
Active Project Grant Awarded Last action
- Award ID
- R01EY035346
- Recipient
-
The Smith-Kettlewell Eye Research Institute UEI VT22KLLMNQL6
- Awarding agency
-
National Eye Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $4,150,842
Award facts
- Assistance listing
- 93.867 Vision Research
- Completion date 91% complete
- Place of performance
- San Francisco, CA 94115, USA
Award details come from USAspending.gov.
Description
- Abstract
- Long-term and chronic visual suppression to the visual input from the non-preferred eye is a key factor in developing amblyopia, or "lazy eye", as well as a critical barrier to treat amblyopia. Amblyopia is commonly caused by misalignment of the eyes (STRABISMUS), chronic optical blur in one eye due to unequal refractive errors in two eyes (ANISOMETROPIA), or a mixture of STRABISMUS and ANISOMETROPIA during early childhood, affecting about 3% to 5% of the population worldwide. Our long-term goal is to understand how and where suppression occurs in the brain. We propose that selective visual attention plays a role in visual suppression. Our hypothesis in the current proposal is that selective visual attention biases competition between eyes and modulates interocular suppression by selectively facilitating responses from the preferred eye and suppressing responses from the non-preferred eye along the visual cortical hierarchy. To test our hypothesis, we will use psychophysics to measure whether valid cueing of the stimulus in the amblyopic eye reduces suppression under dichoptic viewing in adults with amblyopia, compared with invalid/neutral cueing (aim 1). In aim 2, we will use frequency-tagged EEG source imaging along with behavioral measures of perceptual eye dominance during binocular rivalry to compare the effects of selective attention and increased contrast to the amblyopic eye on perception and neural responses. We will simultaneously measure and compare the neural activities along the cortical hierarchy of both eyes under the states of visual perceptual dominance and suppression in adults with amblyopia and normal vision. These measures will help determine: 1) how and where the brain suppresses visually conflicting images in amblyopia; 2) how an increase in bottom-up visual salience by increasing the contrast input to the amblyopic eye changes the neural representation of the amblyopic eye signal and 3) whether paying attention to the amblyopic eye has a similar effect on neural activity as increasing contrast to the amblyopic eye. In aim 3, we will use frequency-tagged EEG source imaging coupled with visual psychophysics to measure cortical activity and behavioral performance during a multiple-object tracking task with moving targets presented to one eye and moving distractors presented to the other eye. This aim will comprehensively characterize: 1) whether visual attention modulates interocular suppression by selectively facilitating neural responses from the preferred eye and suppressing responses from the non-preferred eye along the visual cortical hierarchy (aim 3A); 2) whether there are differences in attentional modulation between normal and amblyopic vision, in terms of temporal dynamics (aim 3B) and attentional resource availability determined by the number of targets to be tracked (aim 3C). The proposed studies will systematically investigate visual perception and neural correlates underlying interocular suppression to provide an integrated picture of visual suppression in amblyopia at physiological levels along the cortical hierarchy as well as perceptual levels. Knowledge gained from our planned studies would help US better understand how and where amblyopic suppression occurs and in turn, will help identify therapeutic strategies for amblyopia.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $503,099 | |
| Amendment | $517,824 | |
| Amendment | $35,000 | |
| Amendment | $35,000 | |
| Amendment | $503,099 | |
| Amendment | $503,099 | |
| Amendment | $503,099 | |
| Amendment | $516,874 | |
| Amendment | $516,874 | |
| Original award | $516,874 |
Quick answers
Who received award R01EY035346?
R01EY035346 was awarded to The Smith-Kettlewell Eye Research Institute by National Eye Institute (National Institutes of Health) on August 1, 2023.
How much is award R01EY035346 worth?
$4,150,842 has been obligated on R01EY035346.
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