Functional testing and quality of life in glaucoma

Active Project Grant Awarded Last action

Award ID
R01EY034554
Recipient
Awarding agency
Obligated
$3,727,026

Award facts

Assistance listing
93.867 Vision Research
Completion date 86% complete
Place of performance
Portland, OR 97232, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
The goal of clinical management in eye care is to protect patients' vision and consequent quality of life. Yet, the impact of vision loss on an individual's quality of life depends not only on its severity, but also on its location within the visual field. Some tasks are predominantly impacted by central visual field loss, while others rely more on differing regions of the peripheral visual field. Thus, two individuals with the same disease severity could have very different experiences of that loss. This is particularly true for glaucoma, which causes localized loss in locations that can differ greatly between individuals. In this project, we will determine the regions of the visual field that most influence different aspects of quality of life. We will derive quantitative metrics of the likely real- world effects of an individual patient's visual field defect that can be obtained without relying on time-consuming and variable questionnaires. These patient-centered metrics can aid clinicians in prioritizing care and choosing appropriate management strategies; and in explaining to an individual patient what the likely consequences are of their disease, both as motivation to maintain medication adherence and so that they can make necessary adjustments to their activities of daily living. In aim 1, we will derive indices predicting the effect of an individual's visual field loss on different patient-reported outcome measures, by parameterizing results from clinical standard automated perimetry, to maximize correlations with results of patient questionnaires from four large studies of ocular hypertension and glaucoma. In aim 2, we will use similar analyses to predict the impact on visual search as measured by a custom-written test, performed on a tablet computer in glaucoma clinic waiting rooms and testing rooms. In aim 3, we will predict the impact of an individual's visual field loss on the visual contribution to balance and subsequent risk of falling, using objective measurements of balance in both high and low ambient light settings. Overall, the project will provide substantial advances in our understanding of the effects of localized visual field loss as caused by glaucoma, and provide invaluable new information for clinicians and patients.

Transactions

Action Obligated Date
Amendment $668,852
Amendment $0
Amendment $0
Amendment $568,586
Amendment $568,586
Amendment $665,042
Amendment $627,980
Original award $627,980

Subawards

Subrecipient Amount Awarded
The Washington University Washington University will provide data collected prospectively over 20 years from the Ocular Hypertension Treatment Study (OHTS). The data will consist of… $108,858
University Of London City ST George's We will further develop, test, and use, the visual search test that we have developed for a tablet computer. We will conduct testing on 300 patients in glaucoma… $406,602
University Of London City ST George's The Crabb lab at City, University of London will further develop, test, and use, the visual search test that we have developed for a tablet computer. We will… $129,333
The Washington University Washington University will provide data collected prospectively over 20 years from the Ocular Hypertension Treatment Study (OHTS). The data will consist of… $35,840
University Of London City ST George's The Crabb lab at City, University of London will further develop, test, and use, the visual search test that we have developed for a tablet computer. We will… $167,196

Quick answers

Who received award R01EY034554?

R01EY034554 was awarded to Legacy Emanuel Hospital & Health Center by National Eye Institute (National Institutes of Health) on September 30, 2023.

How much is award R01EY034554 worth?

$3,727,026 has been obligated on R01EY034554.

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