This Project Grant award, valued at $132,597.00 and provided by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), supports research aimed at improving retinal ganglion cell (RGC) replacement therapies for glaucoma. The research project, conducted by The Schepens Eye Research Institute, Inc., a non-profit organization in Boston, Massachusetts, focuses on investigating the role of neural activity in regulating the integration of transplanted RGCs within the host...
This Project Grant award, provided by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), supports research on how neuronal activity and neurotransmitters, specifically glutamate, influence retinal angiogenesis and blood-retina barrier (BRB) maturation. The $248,999 award to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University will fund a 3-year study to investigate the mechanisms by which synaptic glutamate release regulates deep...
The National Eye Institute (NEI) awarded a $240,000 Project Grant (CFDA 93.867 - Vision Research) to Baylor College of Medicine to conduct research focused on "Characterization of the Nascent Retinal Proteome Regulating Hippo Signaling During Damage." The project aims to use cell type-specific metabolic labeling and purification techniques to identify the immediate molecular regulators of the Hippo signaling pathway in muller glial cells of the damaged mouse retina. This information is...
This $460,625 Project Grant was awarded by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) to Yale University. The grant will fund research to investigate the cellular and synaptic mechanisms underlying changes in retinal ganglion cell (RGC) activity following optic nerve injuries in mouse models of glaucoma. Specifically, the project aims to (1) determine the underlying mechanisms for altered RGC activity after increased intraocular pressure or...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), supports research to evaluate the regenerative potential of human retinal ganglion cells (RGCs) and the regrowth of the optic nerve. The $147,486 award to The Johns Hopkins University aims to identify intrinsic factors that regulate RGC survival, axonal outgrowth, and functional recovery in a regenerative animal model, the zebrafish. The research will also test how modulation of these...
This Project Grant award, totaling $526,841, was provided by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) to Vanderbilt University Medical Center (VUMC). The objective is to investigate the potential role of cyclic guanosine monophosphate (cGMP) signaling in countering retinal ganglion cell (RGC) degeneration in glaucoma. The research aims to discern the effects of cGMP signaling on astrocyte-vascular networks, RGC mitochondrial function, and...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), will support research to investigate the role of myeloid cells in axon degeneration in glaucoma. The $423,767 award to the University of California, Davis will develop and characterize two novel axon injury models to study how NAD+ boosting interventions and immune cell responses impact axonal damage in glaucoma. The research aims to determine if NAD+ based treatments work in a...
This Project Grant award from the National Eye Institute (NEI), part of the U.S. Department of Health and Human Services, under the Vision Research (CFDA 93.867) program, provides $500,500 to support research on the role of retinal ganglion cells in shaping the identity and function of neurons in the superior colliculus visual processing region. The key objectives are to: 1) determine how retinal input influences the morphology and transcriptional profiles of genetically-defined neuron...
This Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), supports research to investigate the combined effects of aging and elevated intraocular pressure (IOP) on the development of glaucoma and retinal ganglion cell (RGC) transcriptomics, as well as determine how transient epigenetic reprogramming using a gene therapy can reverse these age- and glaucoma-specific transcriptomic changes and restore visual function. The total award...
This $499,116 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports research to develop stem cell-derived neuronal relays to regenerate the optic nerve and restore vision. The key objectives are to: 1) measure the functional recovery from long-term optic nerve grafted neural stem cells in the injured visual system, 2) investigate the role of guidance cues on directing neuronal relay axons through the optic chiasm, and 3) target the...