Project Grant R01DK141870
- This $859,704 Project Grant was awarded on July 2, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research by Weill Medical College of Cornell University to investigate the role of the protein AGR2 in regulating host-microbe interactions and inflammatory processes in Crohn's disease. The research aims to enhance understanding of the cellular...
- This federal Project Grant award of $2,076,999 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research on the role of mitochondrial dysfunction in Paneth cells and its relationship to inflammatory bowel diseases, including Crohn's disease. The principal investigator will use a mouse model with Paneth cell-specific deletion of the mitochondrial chaperone protein Prohibitin 1 to...
- This $164,188 federal Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The 5-year grant supports training and research at the University of Washington to study the role of intestinal chondroitin sulfate glycosaminoglycans in inflammatory bowel disease. The research aims to determine how changes in the composition of these gut matrix...
- This federal Project Grant award, with a total funding amount of $645,617, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant is aimed at understanding the dysfunction of hematopoietic stem cells in refractory Crohn's disease, a condition that is resistant to traditional treatments. The research will profile hematopoietic stem cell populations...
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to investigate gut microbial functions that impact Crohn's disease risk. Specifically, the $235,500 award to Rutgers, The State University of New Jersey will generate shotgun metagenomic sequencing data from samples collected from multiplex Crohn's disease families....
- This Project Grant award of $234,000 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at the University of Colorado-Denver to investigate the role of the Aiolos transcriptional regulator in the pathogenesis of inflammatory bowel disease. The researchers aim to utilize CRISPR-Cas9 genome editing to examine how Aiolos regulates T cell...
- This $172,232 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to understand the causes of inflammatory bowel disease (IBD) therapy failure. The principal investigator, Dr. Simon M. Gray, a gastroenterologist at the University of North Carolina at Chapel Hill, will leverage a pre-clinical mouse model to study the immunologic and...
- This federal Project Grant award of $458,047.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to understand how extracellular vesicles (EVs) from intestinal epithelial cells (enterocytes) mediate cell-to-cell communication and function as effectors of inflammation in inflammatory bowel disease (IBD). Specific objectives include identifying...
- This federal Project Grant award of $465,444.00, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate how commensal fungi in the gut can promote intestinal wound repair. The research aims to mechanistically understand how fungi modulate epithelial cells and fibroblasts to enhance crypt regeneration, with a focus on identifying the...
- This federal Project Grant award, titled "PREDICTIVE MODELING OF CD-68 INFLAMMATORY AND ANTI-INFLAMMATORY CHROMATIN PACKING DOMAINS FOR PERSONALIZED BIOMARKER DISCOVERY", is provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $188,538 grant aims to establish a framework that links transcriptomic states with chromatin structure for biomarker...
This $725,520 federal Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at The Johns Hopkins University to understand the role of aberrant N-glycosylation in Crohn's disease (CD) and develop new therapeutic strategies. The research aims to investigate how a genetic mutation in the ZIP8 manganese transporter impairs manganese-dependent N-glycosylation, leading to altered gut microbiome and bile acid homeostasis that exacerbate CD. The project will utilize a mouse model to test whether supplementation with the metabolite UDP-N-acetylglucosamine can restore N-glycan branching deficits and rescue CD-related symptoms. Findings from this 5-year project could inform the development of precision medicine approaches for treating CD.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $725.5k | 9/3/25 |