Project Grant R01DA066583
- The National Institute of Neurological Disorders and Stroke awarded The Ohio State University $10.115 million on September 12, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct a prospective observational study modeling diverse experiences and longitudinal trajectories of acute pain in emergency department settings. The study—titled MODEL-PAIN (MOdeling Diverse Experiences and Longitudinal trajectories of pain)—will enroll 2,400 emergency department patients and...
- The National Institutes of Health National Center for Complementary and Integrative Health awarded Mayo Clinic Jacksonville $780,208 on September 1, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to conduct a randomized controlled trial evaluating the efficacy of a mobile app-based mindfulness intervention for managing chronic pain in persons with spinal cord injury. The study addresses a clinical gap: chronic pain affects 65–85% of people...
- This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on developing novel methods for selectively stimulating nociceptors (pain receptors) and measuring the brain's nociceptive-specific response in both healthy individuals and those with the chronic pain condition fibromyalgia. The $2,314,276 award to Emory University will fund the creation of a new...
- The National Institute of Neurological Disorders and Stroke awarded the University of Massachusetts Lowell $2.272 million on June 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to discover novel, non-opioid, non-addictive analgesics derived from marine microbial natural products. The award funds a phenotypic screening effort combining human induced pluripotent stem cell sensory neurons and glia cultured on multi-well microelectrode arrays to characterize sensory neuron...
- The National Institute of Neurological Disorders and Stroke awarded Massachusetts General Hospital $1.130557 million on August 20, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop a non-viral lipid nanoparticle-delivered gene therapy for acute pain treatment as an alternative to opioids. The project focuses on creating a focal-delivery, non-opioid therapeutic targeting postsurgical pain as the primary indication, with secondary applications to acute exacerbations...
- The National Institute of Neurological Disorders and Stroke awarded The Leland Stanford Junior University $423,500 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to dissociate neural representations of pain and salience using intracranial human brain recordings. The research will obtain intracranial electroencephalography (iEEG) measurements in 20 neurosurgical patients as they perform thermal pain and auditory...
- The National Institute of Neurological Disorders and Stroke awarded Duke University $3.119 million on September 18, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop and validate computational and clinical tools for understanding pain variability in sickle cell disease. The funded work constitutes a prospective cohort study enrolling 1,250 individuals aged 15 years and older living with sickle cell disease in the United States. Over three years, the research...
- The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health under the Department of Health and Human Services, awarded the University of Maryland, Baltimore $4.929 million on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop and validate a multi-omic, psychosocial, and environmental model of individual differences in pain and placebo responses. The project investigates chronic pain conditions, particularly...
- The National Institute of Neurological Disorders and Stroke, a component of the Department of Health and Human Services National Institutes of Health, awarded the University of Florida $603,019 on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to optimize novel REV-ERB agonist compounds for treatment of chronic inflammatory pain. The funded research develops high-affinity REV-ERB agonists with demonstrated in vivo...
- The National Institute of Neurological Disorders and Stroke awarded the Regents of the University of Minnesota a cooperative agreement valued at $769,903 on August 1, 2026, to conduct a feasibility and pilot trial of a novel invasive brain stimulation approach for chronic neuropathic pain. The study combines precision functional mapping and individualized neurostimulation targeting the somato-cognitive action network and cingulo-opercular network—two key circuits in pain processing—to address...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded Mayo Clinic Jacksonville $2,277,111 on September 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop the PAIN (Pain AI Intervention) platform, a wearable sensor-based artificial intelligence system for at-home continuous pain monitoring and personalized opioid management. The project addresses limitations in patient-reported pain scales by deploying validated deep learning algorithms that recognize physiologic patterns associated with pain responses. A multimodal wearable device will capture electrocardiogram, photoplethysmography, electrodermal activity, body movement, temperature, barometric pressure, and oxygen saturation data, supplemented with blood pressure cuff and pulse oximeter measurements, to build objective pain biomarkers and detect signs of over-medication. The platform aims to create real-time, at-home continuous physiologic monitoring data from which machine learning models will estimate pain intensity and opioid response, enabling personalized medication regimens in a closed-loop system. The research plan involves three objectives: characterizing multimodal physiologic and psychosocial signatures of postoperative pain across 500 patients recruited at preoperative consultation; validating machine learning and artificial intelligence models to estimate pain intensity and opioid response; and evaluating acceptability, appropriateness, feasibility, and integration potential of the AI ecosystem in outpatient care. Performance occurs at Mayo Clinic Jacksonville's facility in Jacksonville, Florida. The project period runs from September 15, 2026, through September 14, 2029. This is a project grant, an assistance type supporting defined research activities for a specified period.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.3m | 9/3/26 |