This $1,742,971 federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund research to investigate the epigenetic regulation of inflammasome activation and its modulation by cannabinoids and antiretroviral therapy during chronic SIV infection and cocaine use. The primary objectives are to: 1) Examine the epigenetic mechanisms underlying cannabinoid-mediated reduction of cocaine-induced inflammasome...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $2,223,769.00 to the University of California, San Diego (UCSD) to conduct a comprehensive investigation into the intersection of HIV infection and opioid use on neuroinflammation and neurotoxicity. The 5-year project, running from April 2025 to January 2030, will analyze brain specimens from persons with and without HIV to determine the...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will provide $1,920,359 to Father Flanagan's Boys' Home to conduct research on quantifying cortical-subcortical dynamics in the context of HIV and cannabis use. The research will utilize a next-generation magnetoencephalography (MEG) imaging system to investigate whether HIV-related cognitive deficits are primarily attributable to cortical or...
This Project Grant award, valued at $1,383,618.00, was issued by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant aims to investigate the role of microglia, a type of immune cell in the brain, in mediating the adverse effects of adolescent cannabis use on the maturation of the prefrontal cortex and cognitive function. The key objectives are to: 1) identify the molecular and morphological changes in microglia induced by...
This four-year, $4.6 million project grant from the National Institute on Drug Abuse will fund research at the University of Miami exploring the linkage between cannabis use, route of administration, cannabinoid content, and measures of cardiovascular disease (CVD) risk in people living with HIV (PWH). Specifically, the principal investigator - an interventional cardiologist and physician scientist focused on HIV and CVD prevention - will collect comprehensive data on 300 PWH ages 18-60 to...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support a comprehensive epigenomic analysis to uncover the combined effects of HIV infection and cannabis (CB) use on DNA methylation (DNAm) patterns in specific cell types. The $1,032,192 award, running from September 30, 2024 to July 31, 2029, will enable researchers at Yale University to conduct genome-wide DNAm and methylation...
This Project Grant award of $285,641 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research to investigate the impacts of developmental exposure to cannabinoids, including THC and CBD, on neuroinflammation and persistent behavioral deficits. The University of Mississippi, the award recipient, will leverage its expertise in cannabinoid research and utilize zebrafish models to: 1) assess morphological and behavioral...
This $396,541 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to uncover fundamental mechanisms and key features governing the interactions between antiretroviral drugs (ARVs) and the blood-brain barrier (BBB) components. The overall goal is to improve the ability of ARVs to penetrate and treat HIV infection in the brain. The University of Colorado, as the prime awardee, will employ a physiologically...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $146,922 to The Johns Hopkins University to conduct research on "ENDOCANNABINOID MODULATION OF THE HIV-INDUCED MICROGLIAL INFLAMMATORY RESPONSE". The award period runs from December 17, 2024 to June 16, 2026. This research aims to advance scientific understanding of the interactions between HIV, inflammation, and the endocannabinoid...
This $1,411,610 federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) aims to investigate the combined effects of HIV Tat protein and opioid use on aberrant glial-neuronal interactions and synaptic injury. The research team at the University of Nebraska Medical Center (UNMC) will test the efficacy of engineered, astrocyte-specific AAV vectors expressing short hairpin RNA against microRNA-7 and microRNA-23a to...