Prep and moud rapid access for persons who inject drugs: the chorus+ study

Active Project Grant Awarded Last action

Award ID
R01DA058367
Recipient
Awarding agency
Obligated
$6,507,076

Award facts

Assistance listing
93.279 Drug Use and Addiction Research Programs
Completion date 65% complete
Place of performance
Roxbury, MA 02118, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
The US opioid overdose epidemic has been accompanied by an increase in human immunodeficiency (HIV) among persons who inject drugs. The CO-occurrence of HIV and opioid use disorder (OUD) suggests that a comprehensive approach to OUD and its infectious complications has the potential to improve outcomes. HIV pre-exposure prophylaxis (prep) and medication for opioid use disorder (moud) are evidence-based approaches that are recommended for persons who inject drugs. Unfortunately, these measures have not been widely adopted in real-world settings or accessed by persons at-risk. Foundation for the proposal: the chorus intervention (comprehensive HIV and opioid use disorder response to the unaddressed syndemic) is informed by preliminary research, including: (a) quantitative and qualitative research with persons with substance use disorder, (b) a randomized controlled trial of a peer-delivered motivational intervention demonstrating effectiveness in reducing heroin and/or cocaine use, and (c) preliminary studies demonstrating the feasibility and acceptability of peer-delivered motivational interventions in non-traditional settings. During the chorus pilot phase, we uncovered that prep was initiated late in the intervention. Therefore, we are attempting to accelerate prep initiation by providing HIV self-testing (chorus +) at baseline. The chorus+ intervention includes HIV self-testing, rapid initiation of prep and moud, and a 6-month peer recovery coach to support adherence to these medications. Conceptual model: chorus+ is a theory-based, peer-delivered, mobile phone-supported intervention focused on enhancing uptake and adherence to HIV prep (primary outcome), and receipt of moud (secondary outcome) among persons who inject opioids. Chorus+ aims to improve behavioral skills and self-efficacy while addressing structural barriers. Summary: the current proposal seeks to determine the efficacy of a novel intervention to increase the uptake of evidence-based measures to prevent HIV and treat opioid use disorder. We will compare the chorus+ intervention to usual care (passive referral) among persons who inject opioids (aim 1). In addition, we will examine study implementation to facilitate potential future dissemination using a mixed-methods process evaluation of chorus+ (aim 2). The study will be performed at boston medical center's faster paths clinic, a low-barrier substance use disorder bridge clinic, and through victory programs, which utilizes a mobile outreach van. The proposed intervention will recruit from non-traditional settings in order to reach participants who might not be comfortable in office- based clinics. This project specifically addresses nida's mission of developing effective socio-behavioral interventions to increase uptake of HIV prevention strategies, and accelerating the adoption of evidence-based interventions to address substance use and its infectious complications.

Transactions

Action Obligated Date
Amendment $1,068,172
Amendment $1,113,072
Amendment $1,209,970
Amendment $1,209,970
Amendment $952,946
Original award $952,946

Subawards

Subrecipient Amount Awarded
Trustees Of Boston University "Dr. Sabrina Assoumou, Consortium Principal Investigator, will be responsible for the overall conduct and coordination of the project. Dr. Nancy Scott, SubAward… $123,189
Fenway Community Health Center, Inc. Dr. Mayer will serve as site PI at Fenway Health and will assist the study PI, Dr. Assoumou, by providing expertise on PrEP-related studies including the use of… $19,449
The General Hospital Corporation This study is a two-arm randomized trial to determine the efficacy of CHORUS (Comprehensive HIV and OUD Response to the Unaddressed Syndemic) and collect… $73,416
Fenway Community Health Center, Inc. Dr. Mayer will serve as site PI at Fenway Health and will assist the study PI, Dr. Assoumou, by providing expertise on PrEP-related studies including the use of… $21,549
Emory University Emory University intends to establish a relationship with Boston Medical Center for this five-year study. Dr. Crawford (of Emory University) will collaborate… $12,755
Trustees Of Boston University Dr. Sabrina Assoumou, Consortium Principal Investigator, will be responsible for the overall conduct and coordination of the project. Dr. Nancy Scott,… $143,486
Trustees Of Boston University Goals: To support the implementation of an RCT of a technology-supported CHORUS+ intervention versus usual care for individuals who inject opioids and process… $7,531
Fenway Community Health Center, Inc. Dr. Mayer will serve as site PI at Fenway Health and will assist the study PI, Dr. Assoumou, by providing expertise on PrEP-related studies including the use of… $825
Trustees Of Boston University Dr. Sabrina Assoumou, Consortium Principal Investigator, will be responsible for the overall conduct and coordination of the project. Dr. Nancy Scott,… $50,320
The General Hospital Corporation PrEP and MOUD Rapid Access for Persons who Inject Drugs: the CHORUS+ Study. $84,929
Emory University $16,813
Trustees Of Boston University $50,261
Fenway Community Health Center, Inc. $18,538
Trustees Of Boston University $68,710
Show all 14

Quick answers

Who received award R01DA058367?

R01DA058367 was awarded to Boston Medical Center Corporation by National Institute on Drug Abuse (National Institutes of Health) on September 1, 2023.

How much is award R01DA058367 worth?

$6,507,076 has been obligated on R01DA058367.

On GovTribe

See this award's full record

  • Every transaction and subaward
  • The recipient's other awards and teaming partners
  • Similar grant awards
  • Ask GovTribe AI about this award
Try for free Login