Weighting longitudinal data to access opioid analgesia tapering outcomes among patients with CO-occurring chronic pain and substance use disorder
Active Project Grant Awarded Last action
- Award ID
- R01DA057658
- Recipient
-
Loyola University Of Chicago UEI RFRPFMNR8LA5 Part of Loyola University Of Chicago
- Awarding agency
-
National Institute on Drug Abuse
National Institutes of Health, Department of Health and Human Services
- Obligated
- $6,226,195
Award facts
- Assistance listing
- 93.279 Drug Use and Addiction Research Programs
- Completion date 85% complete
- Originally
- Place of performance
- Maywood, IL 60153, USA
Award details come from USAspending.gov.
Description
- Abstract
- In 2016, the centers for disease control (CDC) released guidelines recommending non-pharmacologic treatment for chronic pain over use of opioid analgesia in response to rising overdose deaths and based on studies showing nonopioid and multidisciplinary approaches to pain contribute to functional and pain severity improvements. CDC guidelines also recommended opioid tapering for chronic pain patients with substance use disorder (SUD) and transition to medications for opioid use disorder (MOUD) for patients with CO-occurring opioid use disorder (OUD). While opioid tapering has been widely implemented, few studies assess transitions to MOUD or multidisciplinary medicine use specifically among patients with chronic pain and CO-occurring SUD. A primary reason for this limited knowledge is the population with chronic pain and CO-occurring SUD is often relatively small in any given healthcare facility or system, and outcomes of interest may occur in low total numbers. Thus, a large database is required to conduct multifactorial research on outcomes associated with different approaches to opioid tapering, especially when evaluating whether trends hold among smaller demographic groups. To address this critical GAP, our goal is to create weights for the cerner real-world© database, which includes electronic health records (EHR) data from over 100 million unique U.S. Patients at 600 participating hospitals and clinics. Our hypothesis is that weighting the database will significantly enhance its representativeness in order to longitudinally assess the relationship between opioid tapering, multidisciplinary medicine, MOUD, and outcomes for chronic pain patients with CO-occurring SUD. Our aims are to use american hospital association and U.S. Census data to create weights, stratified by hospital characteristics and adjusted by demographic variables, for analyzing the cerner database (aim 1); validate the weighting scheme in aim 1 by comparing weighted estimates from the cerner database to estimates from a well-established population (the nationwide inpatient sample) for chronic pain, SUD, and overdose diagnoses and relevant multidisciplinary pain interventions for the years 2000-2025 (aim 2); among patients with chronic pain and CO-occurring OUD, examine how tapering opioid analgesics and transitioning to MOUD affects risk for overdose, suicide, and other hospitalizations, and assess how SEX and race/ethnicity operate as effect modifiers in these relationships (aim 3); and among patients with chronic pain and CO-occurring SUD, examine how tapering opioid analgesics while using multidisciplinary pain treatment affects risk for overdose, suicide, and other hospitalizations, and assess how SEX and race/ethnicity operate as effect modifiers in these relationships (aim 4). This project will create a national database with validated weighting that will enable rigorous examination of opioid tapering approaches among patients with chronic pain and CO-occurring SUD, which will subsequently improve knowledge of how multidisciplinary pain treatment and MOUD affect risks, while considering tapering-related inequities among demographic subpopulations.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $678,239 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $680,457 | |
| Amendment | $680,457 | |
| Amendment | $0 | |
| Amendment | $2,093,521 | |
| Original award | $2,093,521 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Regents Of The University Of Michigan | $29,481 | |
| Western Michigan University Homer Stryker M.d. School Of Medicine | $70,614 | |
| Wayne State University | $47,175 | |
| Western Michigan University Homer Stryker M.d. School Of Medicine | $235,197 | |
| Regents Of The University Of Michigan | $144,226 | |
| Wayne State University | $144,226 |
Quick answers
Who received award R01DA057658?
R01DA057658 was awarded to Loyola University Of Chicago by National Institute on Drug Abuse (National Institutes of Health) on September 30, 2022.
How much is award R01DA057658 worth?
$6,226,195 has been obligated on R01DA057658.
On GovTribe
See this award's full record
- Every transaction and subaward
- The recipient's other awards and teaming partners
- Similar grant awards
- Ask GovTribe AI about this award