Development of an automated, point of care DNA methylation cartridge blood test for colorectal cancer detection in lmics- an academic-industrial partnership
Active Project Grant Awarded Last action
- Award ID
- R01CA278816
- Recipient
-
The Johns Hopkins University UEI FTMTDMBR29C7
- Awarding agency
-
National Cancer Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $4,600,682
Award facts
- Assistance listing
- 93.394 Cancer Detection and Diagnosis Research
- Completion date 68% complete
- Place of performance
- Baltimore, MD 21205, USA
Award details come from USAspending.gov.
Description
- Abstract
- Colorectal cancer (CRC) is diagnosed at advanced stages in many low- and middle-income countries (lmics). The lack of knowledge of CRC signs and symptoms by patients and community health practitioners frequently leads to delayed presentation with stage 3-4 disease. This initial delay, paired with limited colonoscopy facilities, leads to prolonged diagnostic delays. The result is a 5-year mortality rate in lmic up to 5 times higher than that in USA. An innovative solution to this problem could be an affordable, easily deployable, "point of care" molecular test to identify and prioritize patients likely to have a malignancy for expedited colonoscopy and pathology review leading to better outcomes. Continuing our established collaboration with our industrial partner, cepheid, we propose to build on our strong published data on hypermethylated markers in CRC to develop an affordable,
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $107,249 | |
| Amendment | $488,110 | |
| Amendment | $488,110 | |
| Amendment | $107,645 | |
| Amendment | $107,645 | |
| Amendment | $107,645 | |
| Amendment | -$50,988 | |
| Amendment | -$50,988 | |
| Amendment | -$50,988 | |
| Amendment | $509,917 | |
| Amendment | $509,917 | |
| Amendment | $544,861 | |
| Amendment | $544,861 | |
| Amendment | $618,843 | |
| Original award | $618,843 |
Show all 15
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Cepheid | $429,509 | |
| Obafemi Awolowo University | $214,894 | |
| Sloan-Kettering Institute For Cancer Research | $233,381 | |
| Obafemi Awolowo University TE Aching Hospital Complex | $297,240 |
Quick answers
Who received award R01CA278816?
R01CA278816 was awarded to The Johns Hopkins University by National Cancer Institute (National Institutes of Health) on June 6, 2023.
How much is award R01CA278816 worth?
$4,600,682 has been obligated on R01CA278816.
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