Establishing the clinical utility of a consensus DSC-MRI protocol

Active Project Grant Awarded Last action

Award ID
R01CA264992
Recipient
Awarding agency
Obligated
$4,598,960

Award facts

Assistance listing
93.394 Cancer Detection and Diagnosis Research
Completion date 78% complete
Originally
Place of performance
Houston, TX 77030, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
This multi-site study aims to establish best practice recommendations and clinical value of a new consensus protocol for dynamic susceptibility contrast (DSC) MRI. DSC-MRI is one of the most widely used physiologic imaging techniques in neuro-oncology, with a reported use in 85% of all routine brain tumor scans at sites across the US and europe. DSC-MRI measures of relative cerebral blood volume (RCBV) can differentiate glioma grades, identify tumor components in non-enhancing glioma, distinguish tumor recurrence from post-treatment effects (including pseudoprogression and radiation necrosis) and predict treatment response and patient survival after targeted therapy. Despite this demonstrated value, translation of consistent clinical DSC-MRI guidelines across multiple institutions remains challenging owing to variability in acquisition and post-processing protocols. To improve the accuracy, repeatability, and multi-site consistency of DSC-MRI, the team of investigators on this proposal identified and validated a DSC-MRI protocol that has since become a consensus recommendation for patients with glioma. Accordingly, we are well positioned to address critical gaps in this field that, once solved, will accelerate the widespread adoption of the consensus protocol and direct its use in clinical practice. We first aim to establish best practices for the pre- and post-processing methods for DSC-MRI. We will then leverage our expertise with image-localized biopsies and matched image-tissue correlations to establish guidelines for interpreting RCBV maps generated with the consensus protocol, specifically applied to the differentiation of low- from high-grade glioma, and progression of high-grade glioma from post-treatment effects. Finally, we aim to establish the clinical value added of the consensus DSC-MRI protocol for impacting brain tumor patient management. These studies will address key practical and clinical unmet needs that will directly facilitate the future use of DSC-MRI in glioma patients, thereby promoting widespread adoption of the consensus DSC-MRI protocol.

Transactions

Action Obligated Date
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Amendment $765,016
Original award $765,016
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Subawards

Subrecipient Amount Awarded
Mayo Clinic Arizona The goal of this project is to improve patient care by validating, across multiple institutes, that a consensus DSCMRI protocol yields measures of relative… $567,044
Froedtert & The Medical College Of Wisconsin As a team we have recently accomplished the publication of the national consensus regarding how to collect DSC-MRI data in patients with brain tumors. This… $683,720
Rhode Island Hospital The goal of this project is to formally establish best practice recommendations and clinical value of a new consensus protocol for dynamic susceptibility… $388,176

Quick answers

Who received award R01CA264992?

R01CA264992 was awarded to The Univeristy Of Texas M.d. Anderson Cancer Center by National Cancer Institute (National Institutes of Health) on March 1, 2022.

How much is award R01CA264992 worth?

$4,598,960 has been obligated on R01CA264992.

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