Understand and mitigating the influence of extreme weather events on HIV outcomes: a global investigation

Active Project Grant Awarded Last action

Award ID
R01AI179420
Recipient
Awarding agency
Obligated
$4,860,727

Award facts

Assistance listing
93.855 Allergy and Infectious Diseases Research
Completion date 80% complete
Place of performance
New York, NY 10027, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
The health challenges arising from extreme weather events (ewes), such as droughts, floods, and major storms (e.g., hurricanes, typhoons) are increasingly common and severe, threatening to undermine public health progress made over the past century. There is limited evidence on how ewes affect care outcomes among the 37 million people living with HIV/aids (plwh), particularly in geographic regions most vulnerable to ewes. Cross-sectional studies have shown both drought and excess rainfall to be associated with higher HIV prevalence. However, very little is known about how ewes impact short- and long-term HIV care outcomes. Our preliminary analysis of data from 11 sub-saharan african countries found that extreme rainfall may delay the timely initiation of antiretroviral therapy (art) and increase loss to follow-up among those newly enrolling in HIV care. Our preliminary qualitative work in kenya suggests that exposure to drought and flooding adversely affects HIV outcomes through decreased food availability and art adherence and increased infectious disease incidence. The absence of rigorous longitudinal assessments of the relationships and causal pathways between EWE exposures and HIV care outcomes remains a crucial GAP in knowledge and obstacle to intervention development. The global iedea cohort collaboration, with >2 million plwh enrolled in HIV care in 44 countries over a long time horizon (2004-present) provides an unparalleled opportunity to characterize the influence of ewes on HIV care outcomes across several geographic contexts and sub-populations of plwh (e.g., those with advanced disease, adolescents, those who are pregnant, etc). The proposed 5-year, mixed methods study will combine high resolution daily data on temperature and rainfall from five publicly available climate datasets with the global iedea cohort data from 2004-present to longitudinally assess the impacts of ewes on HIV care outcomes (timely art initiation HIV viral load monitoring, and HIV viral suppression) (aim 1). In aim 2, we will use a mixed methods approach to explore subgroups of vulnerability and resilience to ewes among plwh, mechanisms of impact, and adaptation and mitigation strategies employed in specific communities to inform interventions. In aim 3, we will create and disseminate a country-level public use climate dataset with geocoded temperature and rainfall data going back to 1984 for ready use by other investigators, program implementers, and policymakers. We expect this novel study to inform climate mitigation and adaptation strategies, and lay the groundwork for the development of other targeted (population and region-specific) interventions to address deleterious health effects of ewes. Moreover, we expect our study to have significant implications for global health programs, policies, mathematical modelers and funders, creating new health-related applications for climate datasets.

Transactions

Action Obligated Date
Amendment $70,498
Amendment $38,783
Amendment $792,803
Amendment $0
Amendment $0
Amendment $20,072
Amendment $36,151
Amendment $20,072
Amendment $36,151
Amendment $729,545
Amendment $729,545
Amendment $802,257
Original award $792,047
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Subawards

Subrecipient Amount Awarded
Research For Development Charles Ingabire, Co-Principal Investigator, will oversee the project’s qualitative component consisting of in-depth interviews with individuals and key… $32,817
Ateneo De Manila University Inc. Dr.'s Tim Dizon and Gelo Apostol serve as coordinators of the Philippines filed-research team. They will participate in weekly planning meetings and plan a site… $94,155
Icahn School Of Medicine At Mount Sinai Scope of Work: 1. **Geospatial Leadership: - Oversee the geospatial analytical efforts for the project. - Direct the development of methodologies to assess… -$69,498
Research For Development Charles Ingabire, Co-Principal Investigator, will oversee the project’s qualitative component consisting of in-depth interviews with individuals and key… $96,059
Icahn School Of Medicine At Mount Sinai Scope of Work: 1. **Geospatial Leadership: - Oversee the geospatial analytical efforts for the project. - Direct the development of methodologies to assess… $104,244
The Regents Of The University Of California. San Francisco We propose a five-year, mixed-methods study that will leverage two large existing observational cohorts to longitudinally assess the specific relationships… $127,496
University Of California, Santa Barbara Overall Scope The UCSB team will provide domain expertise along with statistical and computational guidance in linking extreme weather events (EWEs) to specific… $53,879
Icahn School Of Medicine At Mount Sinai Scope of Work: 1. **Geospatial Leadership: - Oversee the geospatial analytical efforts for the project. - Direct the development of methodologies to assess… $34,746
The Regents Of The University Of California. San Francisco We propose a five-year, mixed-methods study that will leverage two large existing observational cohorts to longitudinally assess the specific relationships… $93,005
University Of California, Santa Barbara Overall Scope The UCSB team will provide domain expertise along with statistical and computational guidance in linking extreme weather events (EWEs) to specific… $51,934

Quick answers

Who received award R01AI179420?

R01AI179420 was awarded to Research Foundation Of The City University Of New York by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on August 21, 2023.

How much is award R01AI179420 worth?

$4,860,727 has been obligated on R01AI179420.

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