The impact of non-dysentery shigella-associated diarrhea in children
Active Project Grant Awarded Last action
- Award ID
- R01AI153399
- Recipient
-
The Johns Hopkins University UEI FTMTDMBR29C7
- Awarding agency
-
National Institute of Allergy and Infectious Diseases
National Institutes of Health, Department of Health and Human Services
- Obligated
- $10,162,441
Award facts
- Assistance listing
- 93.855 Allergy and Infectious Diseases Research
- Completion date 95% complete
- Originally
- Funding
-
- $9,301,879.42 Federal
- $860,561.21 Non-federal
- Place of performance
- Baltimore, MD 21205, USA
Award details come from USAspending.gov.
Description
- Abstract
- Shigella is a primary cause of moderate-to-severe diarrhea in children living in impoverished areas of the world. Shigella is known for causing dysentery (blood in stool). However, majority of the children infected with shigella present with watery diarrhea. The current world health organization (who) guidelines for treatment of shigellosis (in the absence of a rapid, sensitive, simple and inexpensive diagnostic test) recommends treatment with antibiotics when presence of visible blood in stool. Thus, the non-dysentery shigella associated diarrhea (NDSD) cases would not be treated with antibiotics. Absence of dysentery may not indicate a low risk of death and does not exclude shigella as a cause of diarrhea. In particularly vulnerable younger children or with malnutrition, identification and treatment of shigella infection might be life-saving. IT may be hypothesized that NDSD cases, if identified quickly, should be treated with antibiotics to improve survival and long-term developmental potential in children. Identification of such cases will require a rapid test to document these infections so that treatment can be initiated promptly, and evidence based. To address these questions, we propose to conduct a prospective longitudinal case control study to understand the pathophysiology of NDSD and the impact of NDSD in children compared to dysentery shigellosis. The children seeking care in the hospital in bangladesh with diarrhea (both dysentery and NDSD), that is positive for shigella and a third group with shigella negative watery diarrhea will be enrolled and prospectively followed. Our study has the following specific aims: aim 1. Determine morbidity and risk of hospitalization associated with NDSD cases and its impact on nutritional status and cognitive development of the children. Aim 2. Understand the impact of NDSD on GUT barrier function, systemic and GUT inflammation in children. Aim 3. Evaluate if the simple and rapid test S-rldt could be applicable for case detection and treatment of shigellosis in the clinical settings of the rural hospitals of the endemic countries. Collectively, our proposed research would broadly impact the field by understanding the pathophysiology of NDSD and the impact of NDSD in child health. This study will help to understand if there is a need to change the current guidelines of shigellosis treatment for better survival and development of the children. This study will also validate a rapid test capable of identifying the patients who will benefit from antibiotics.
Transactions
| Action | Federal | Non-federal | Date |
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| Amendment | $0 | $0 | |
| Amendment | $722,477 | $0 | |
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| Amendment | $667,137 | $0 | |
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| Amendment | $665,901 | $0 | |
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| Amendment | $453,808 | $0 | |
| Amendment | $453,808 | $453,808 | |
| Amendment | $406,753 | $0 | |
| Original award | $406,753 | $406,753 |
Show all 18
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| International Centre For Diarrhoeal Disease Research, Bangladesh | $941,048 |
Quick answers
Who received award R01AI153399?
R01AI153399 was awarded to The Johns Hopkins University by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on March 9, 2021.
How much is award R01AI153399 worth?
$10,162,441 has been obligated on R01AI153399: $9,301,879 in federal funding and $860,561 in non-federal funding.
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