Project Grant R01AG100834
- This $410,000 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to develop an evidence base for using intracranial EEG (iEEG) to investigate how noninvasive stimulation can modulate hippocampal network activity and affect memory. The research has three primary objectives: 1) investigating the selectivity of hippocampal indirectly targeted stimulation (HITS) on iEEG activity, 2) testing whether HITS impacts...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Trustees of Columbia University in the City of New York, doing business as the Health Sciences Division, a $2,554,313 federal Project Grant under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372). The grant, which runs from Sep 1, 2023 to Aug 31, 2026, will support research to determine if targeted in vivo manipulations of local circuit control...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $489,197 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the Research Foundation For Mental Hygiene, Inc. (RFMH) for the project "Neural Circuits of Cue and Spatial Representation in the Dentate Gyrus". The project aims to examine the microcircuitry of how cue and spatial information are processed in the dentate gyrus region of the...
- This federal Project Grant award, valued at $358,313.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award will fund a 5-year research study at Drexel University to investigate how prior knowledge shapes the learning and long-term consolidation of new memories in healthy human adults. The research will utilize functional neuroimaging (fMRI) and...
- This $449,228 Project Grant from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will enable Neuronexus Technologies, Inc. (doing business as Nuvectra) to develop an integrated system for large-scale, chronic extracellular neural recording and stimulation in human brain organoids. The project aims to 1) create advanced biological assay chambers to support chronic electrophysiology while maintaining organoid health, 2) develop...
- This federal Project Grant award for $633,438, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to develop a data-driven framework for real-time neural control using patterned microstimulation. The research aims to investigate the principles governing multi-electrode microstimulation in the primate prefrontal cortex, and introduce a novel data-driven algorithm to predict optimal stimulation patterns. The...
- This federal Project Grant award of $498,429, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to identify the key factors that determine an individual's response to transcranial direct current stimulation (tDCS). The research aims to apply machine learning algorithms to a large, multimodal dataset of over 225 tDCS-fMRI sessions to determine which factors, such as baseline task performance, brain...
- This federal Project Grant award of $417,200.00, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), will support research to characterize and manipulate large-scale brain activity patterns associated with attention, focus, and psychiatric/neurological disorders. The project aims to 1) determine whether patterns of quasi-periodic brain activity observed in functional MRI data reflect underlying neural activity patterns...
- The federal Project Grant award of $1,440,000.00 from the Department of Health and Human Services National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310), awarded to Northwestern University on August 1, 2025, aims to develop a transformational approach to reprogram brain cells and enhance their resilience against a broad array of neurodevelopmental diseases. The project, titled "Perinatal Brain Therapeutics: A High Throughput Biology Approach to Build Next...
- This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the federal Research Related to Deafness and Communication Disorders program (CFDA 93.173), is providing $1,575,486.00 to the University of Chicago to develop experimental approaches that use noninvasive brain stimulation to directly test how the hippocampal network supports episodic memory. The project aims to identify neural activity patterns in the hippocampal network related to...
This federal Project Grant award from the National Institutes of Health's Trans-NIH Research Support program (CFDA 93.310) provides $547,998 to The Nemours Foundation to conduct research on "Restoring Cognitive Function Through Precision Neurostimulation: A Disease-Agnostic Approach Based on Convergent Hippocampal Dynamics." The research aims to revolutionize the treatment of cognitive dysfunction across various neurological disorders by correcting disrupted brain activity patterns in the hippocampus, a key brain region involved in memory and emotional regulation. The project will utilize six animal models of common neurological conditions to define similar abnormalities in hippocampal dynamics and evaluate whether brain stimulation can improve both brain activity and cognitive performance. The research will also include in-silico experiments to model a range of pathophysiological processes and stimulation parameters. This iterative approach combining in-vivo and in-silico methods is intended to accelerate the clinical translation of the findings, with the goal of developing innovative therapies to improve cognitive function and quality of life for individuals with various neurological disorders.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $548.0k | 9/15/25 |