Project Grant R01AG094133
- The National Institute on Aging awarded Beth Israel Deaconess Medical Center, Inc. $475,475 on July 15, 2026, under the Aging Research program (CFDA 93.866) to investigate suburothelial myofibroblast function in young and aging bladder tissue. The research addresses lower urinary tract symptoms affecting the aging population by examining how suburothelial myofibroblasts (SUMFs)—interstitial cells beneath the bladder's urothelial lining—contribute to normal bladder function and dysfunction during...
- The National Institute on Aging awarded Beth Israel Deaconess Medical Center, Inc. $475,475 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate neural mechanisms underlying nocturia-related arousals in aging. The recipient will conduct research examining why 60–70 percent of individuals aged 60 and older experience frequent nighttime bladder emptying trips despite absence of urodynamic dysfunction. The study hypothesizes that decreased arousal threshold...
- The National Institutes of Health Office of the Director awarded the University of California Irvine $863,500 on September 18, 2025, under the Trans-NIH Research Support program (CFDA 93.310) to develop anti-fibrogenic therapy targeting aging-associated urethral dysfunction. The research investigates mechanisms by which aging impairs urethral physiology and urinary continence in women. Preliminary studies in aged female mice demonstrated substantially lower functional leak point pressure and...
- The National Institute on Aging awarded $1.564 million to the University of Texas Southwestern Medical Center on February 1, 2026, under the Aging Research program (CFDA 93.866) to fund research on cellular senescence and pelvic organ prolapse development. The award supports a five-year project running through January 31, 2031. The funded research tests the hypothesis that cellular senescence drives pelvic organ prolapse (POP) during aging using single-cell and single-nuclei RNA sequencing and...
- The National Institutes of Health Office of the Director awarded the University of Texas at Dallas $482,997 on September 15, 2025, under the Aging Research program (CFDA 93.866) to investigate the impact of estrogen hormone therapy modality on urobiome dynamics in postmenopausal women at risk for recurrent urinary tract infection. The research examines how different estrogen hormone therapy modalities alter the urinary microbiome in postmenopausal women, with focus on lactobacillus...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Rancho Research Institute $727,810 on June 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate functional and structural brain connectivity alterations in post-stroke lower urinary tract dysfunction and to identify biomarkers predicting response to transcutaneous spinal cord stimulation therapy. The research combines three integrated aims. Aim 1 uses...
- GRANT AWARD SUMMARY Baylor College of Medicine received a $3.00 million Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) effective September 15, 2025, through August 31, 2029. The award funds fundamental research investigating the mechanisms underlying age- and sex-dependent changes in urinary bladder immunity, with particular focus on understanding...
- The National Institute on Aging awarded Mayo Clinic $678,684 under the Aging Research program (CFDA 93.866) on September 1, 2026, to investigate the neural mechanisms of respiratory dysfunction in older age. The research explores how impaired autophagy in phrenic motor neurons contributes to selective loss of higher-force motor units with advancing age, and whether restoring autophagy prevents this loss. The project employs loss-of-function and gain-of-function experiments using conditional...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $642,712 to The University of Texas Southwestern Medical Center on June 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate adult neurogenesis as a strategy for improving urinary function after contusion spinal cord injury. The project systematically examines...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded the University of Missouri System $676,608 on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of the gut-brain axis in Alzheimer's disease mitigation through a translational study combining human and preclinical animal experiments. The project examines how dysbiosis—microbial imbalance—correlates with Alzheimer's disease biomarkers (amyloid plaques, tau...
The National Institute on Aging awarded The Methodist Hospital Research Institute $665,617 on September 15, 2026, under the Aging Research program (CFDA 93.866) to identify age and sex-dependent contributions to supraspinal mechanisms involved in underactive bladder dysfunction. The research addresses the poorly understood neurological underpinnings of underactive bladder (UAB), which presents with symptoms including slow urinary stream, hesitancy, and incomplete emptying. UAB predominantly affects older adults and, if untreated, increases risks of recurrent urinary tract infection, renal failure, and bladder stones; current therapies including catheterization have limited efficacy and poor compliance. The project will investigate altered supraspinal neural network activity during the bladder filling and storage-voiding cycle using functional magnetic resonance imaging to identify brain regions of interest that may serve as targets for supraspinal neuromodulation, building on evidence that such abnormal activity is a hallmark of aging-associated lower urinary tract symptoms. Performance of work occurs in Houston, Texas, with a period of performance extending through May 31, 2031. The Methodist Hospital Research Institute, a nonprofit biomedical research organization and division of The Methodist Hospital, serves as the recipient organization.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $665.6k | 9/3/26 |