This $1,505,109 Project Grant awarded by the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), aims to identify undiagnosed Alzheimer's disease (AD) in non-Hispanic White, Hispanic/Latino, and non-Hispanic African American populations. The project will leverage electronic health records and genetic data to develop disease trajectory models and polygenic risk scores to detect undiagnosed AD, while addressing the issue of underdiagnosis in underserved...
This Project Grant award of $4,787,820.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to gain a better understanding of the individual- and system-level characteristics that influence diagnosis of mild cognitive impairment (MCI) and Alzheimer's disease and related dementias (ADRD), and how diagnosis can moderate the effects of cognitive decline on employment, future care, and quality of life. The key objectives are to: 1) examine whether older adults experiencing...
This Project Grant award of $2,763,221 from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), aims to examine the impact of physician, hospital, and skilled-nursing facility factors related to geriatric care on days spent at home among persons with Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD). The study, conducted by Cedars-Sinai Medical Center, will use Medicare data linked to other nationally representative...
This Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) provides $3,845,311 to the University of California, San Diego (UCSD) to investigate the early determinants of Alzheimer's disease (AD) using age-equivalent neurons derived from mild cognitive impairment (MCI) patients. The project aims to better understand the convergence of risk factors, including polygenic variants and biological aging, on molecular pathways that initiate and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $663,376 to The Regents of the University of California, San Francisco to explore the molecular mechanisms underlying the heterogeneity of Alzheimer's disease and related dementias. The project aims to identify key genes that mediate the selective vulnerability of brain regions to distinct pathological protein conformers, such as tau and alpha-synuclein, using a novel computational modeling...
This Project Grant award of $2,557,260.00 from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) will support a longitudinal study to investigate the transition from midlife to early late-life and the development of early clinical Alzheimer's disease and related dementias (AD/ADRD) among diverse populations. The study, led by the University of California, San Francisco, will conduct cognitive assessments and AD/ADRD adjudication on participants in the...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) for $791,086 aims to develop computational models that can predict the presence of non-Alzheimer's disease neuropathological changes, such as Lewy body disease, TDP-43 proteinopathy, and cerebral amyloid angiopathy, in individuals with Alzheimer's disease neuropathological changes. The project will leverage data from autopsy-confirmed datasets, in vivo neuroimaging, and clinical assessments to build...
The Project Grant award R01AG087243, totaling $3,374,303 and awarded by the National Institute on Aging (CFDA 93.866 - Aging Research), will fund the "Understanding Ambulatory Care Utilization in Alzheimer's Disease and Related Dementias (ACUA)" project. This project aims to investigate the role of fragmented ambulatory care in the diagnosis and management of people living with dementia. The key products and services to be delivered include: Secondary analyses of two NIA-funded...
This $1,230,000 Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) will support the development and deployment of closed-loop digital interventions through a remote clinical trials platform. The overarching goal is to leverage technology to facilitate memory and cognitive function and prevent or delay age-related cognitive decline, particularly in older adults at risk of Alzheimer's disease and related dementias. The...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,929,011 to The Regents of the University of California, San Francisco (UCSF) to conduct a longitudinal, multimodal neuroimaging study investigating the role of neuronal dysfunction and hyperexcitability in the early biological progression of Alzheimer's disease. The study aims to elucidate the earliest manifestations of neural circuit hyperexcitability that predict the accumulation of tau...