Social epigenetics of alzheimer's disease and related dementias in latin american countries

Active Project Grant Awarded Last action

Award ID
R01AG082056
Recipient
Awarding agency
Obligated
$7,377,465

Award facts

Assistance listing
93.866 Aging Research
Completion date 50% complete
Place of performance
La Jolla, CA 92093, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
(ABSTRACT) alzheimer's disease (ad) and related dementias like frontotemporal dementia (FTD) disproportionately affect latinos and socioeconomically disadvantaged groups. Nevertheless, the bulk of the research exploring the multifaceted biology of dementia, which includes both genetic and epigenetic aspects, has predominantly been focused on caucasian populations and higher-income countries (HICS). To address these disparities and expand dementia research in latin america countries (LAC) and low-income countries, our group has established the NIH-NIA/TAU consortium/alzheimer association funded multi-partner consortium to expand dementia research in latin america (REDLAT) cohort study of latinos with ad, FTD, and healthy controls. REDLAT represents a first-in-class dataset of latinos with ad, FTD, and demographically matched healthy controls consisting of biospecimen collection, standardized clinical, neuropsychological, genomic, neuroimaging, and SDH data, which our research group has utilized to identify unique combinations of environmental and genetic factors of dementia in latin american countries (LAC). Our preliminary epigenetic data reveals shared and distinct epigenetic DNA methylation differences related to ad and FTD, including a "hispanic paradox" with epigenetic biomarkers underestimating biological aging in latinos despite ad and FTD diagnoses. Moreover, our preliminary data harnessing matched SDH data from REDLAT suggests a link between altered dnam states of inflammatory, stress, and cardiometabolic genes and socioeconomic status. Our overall hypothesis is that a social adversity-epigenetic signature in immune cells at regulatory regions of proinflammatory, stress, and cardiometabolic genes associates with dementia presentation and heterogeneity in latinos. In this proposal, we test this overall hypothesis and add epigenetic dnam data to the REDLAT cohort by (1) leveraging existing blood biospecimens from 1,600 participants (N=400 ad, N=400 FTD, N=800 controls) with different social determinants of health (SDH) levels, including a low-middle income country (COLOMBIA), an upper middle-income country (ARGENTINA), and HICS countries (chile and the US) and (2) leverage existing ongoing rolling REDLAT recruitment to add an out-of-sample validation epigenetic dataset of 400 additional participants (N=100 ad, N=100 FTD, and N=200 controls) to generate an epigenetic dataset from 2,000 total latinos in REDLAT. With these rich epigenetic data, we will identify shared and distinguishing epigenetic dnam features associated with ad and FTD presentation in latinos. Moreover, we will utilize this extensive epigenetic dataset to better understand the interactions between specific SDH factors and distinct epigenetic changes in the genome. Understanding dementia presentation through the lens of epigenetics and SDH in latinos across diverse regions of LAC and the US will advance regionally-informed novel strategies to address dementia disparities by paving the way for targeted interventions and prevention strategies that take into account both epigenetic and SDH factors.

Transactions

Action Obligated Date
Amendment $1,191,371
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Original award $1,199,134
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Subawards

Subrecipient Amount Awarded
Pontificia Universidad Javeriana PI of Prime Grant to Cornell Institute: Michael Corley PI of Subcontract: Hernando Santamaria Period of Performance: April 1, 2024 – March 31, 2029… $602,316
Universidad Adolfo Ibanez Project Title: Social epigenetics of dementia in LAC PI of Prime Grant to Cornell Institute: Michael Corley PI of Subcontract: Agustín M. Ibañez Period of… $729,432
Fundacion Universidad De Antioquia WORKSCOPE STATEMENT FOR Universidad de Antioquia Project Title: Social epigenetics of Alzheimer's disease and related dementias in Latin American countries PI… $141,156
The Regents Of The University Of California. San Francisco UCSF will participate in the prime grant awarded to Weill Cornell to support the study of epigenetic biomarkers of dementia and their association with… $204,737

Quick answers

Who received award R01AG082056?

R01AG082056 was awarded to University Of California, San Diego by National Institute on Aging (National Institutes of Health) on June 1, 2024.

How much is award R01AG082056 worth?

$7,377,465 has been obligated on R01AG082056.

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