Novel neuromodulation treatment of age related vestibular loss to improve balance and gait in elderly individuals

Active Project Grant Awarded Last action

Award ID
R01AG073161
Recipient
Awarding agency
Obligated
$7,084,486

Award facts

Assistance listing
93.866 Aging Research
Completion date 89% complete
Originally
Funding
  • $6,538,305.00 Federal
  • $546,181.00 Non-federal
Place of performance
Boston, MA 02114, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Loss of neural function is a common problem with aging and disease. To treat this loss, current neural stimulators have used various forms of stimulation that putatively activate neurons to elicit neuromodulation. Generally these stimulators rely on a fixed frequency and amplitude stimulus. Recently, we have found that subperceptual levels of random electrical stimulation applied to the vestibular system produce improvements in vestibular-mediated reflex function, balance and gait demonstrating the use of low levels of electrical stimulation to enhance the natural neural signaling of the vestibular system without exogenous stimulus. The goal of this present work is to demonstrate the sustained improvement of balance and gait by applying low levels of random electrical stimulation to the vestibular system of elderly individuals with vestibular hypofunction. We hypothesize that elderly participants will display functional improvement with sustained low levels of random electrical stimulation. This work will establish parameters for viable treatment of age related vestibular loss in elderly individuals using safe and effective amounts of electrical stimulation.

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Subawards

Subrecipient Amount Awarded
Western Sydney University Dr. Breen will be integral to the investigation of this proposal. Dr. Breen and his team will be building and modifying the electrical stimulators that will… $173,180
The Johns Hopkins University Dr Schubert is vestibular physiologist with expertise in diagnosis of vestibular dysfunction. In addition Dr. Schubert is clinically trained as a physical… $118,063
Western Sydney University Dr. Breen will be integral to the investigation of this proposal. Dr. Breen and his team will be building and modifying the electrical stimulators that will… $173,502

Quick answers

Who received award R01AG073161?

R01AG073161 was awarded to Massachusetts Eye And Ear Infirmary by National Institute on Aging (National Institutes of Health) on September 30, 2021.

How much is award R01AG073161 worth?

$7,084,486 has been obligated on R01AG073161: $6,538,305 in federal funding and $546,181 in non-federal funding.

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