Contribution of longitudinal neighborhood determinants to cognitive health and dementia disparities within a multi-ethnic cohort
Active Project Grant Awarded Last action
- Award ID
- R01AG072634
- Recipient
-
Drexel University UEI XF3XM9642N96
- Awarding agency
-
National Institute on Aging
National Institutes of Health, Department of Health and Human Services
- Obligated
- $17,981,697
Award facts
- Assistance listing
- 93.866 Aging Research
- Completion date 54% complete
- Originally
- Funding
-
- $16,833,971.00 Federal
- $1,147,726.00 Non-federal
- Place of performance
- Pennsylvania, USA
Award details come from USAspending.gov.
Description
- Abstract
- Beyond the role that individual factors (e.g. age, race, gender, and socioeconomic status) play in the progression of alzheimer's disease and related dementias (ADRD), neighborhood factors (e.g. social and built environments) may affect cognitive health. Critically, although african american and hispanic individuals face the highest and most disproportionate risk for ADRD, research has traditionally excluded diverse populations. Given historic and current patterning of healthy neighborhood factors by racial and socioeconomic characteristics, these features may partially explain observed disparities in ADRD risk. To date there has been no research on the role of neighborhood environments in disparities in ADRD risk. In this study, we propose to leverage and extend extensive longitudinal data from the multi-ethnic study of atherosclerosis (MESA) to address major gaps in research on neighborhoods and disparities in ADRD. We propose to undertake large-scale collection, processing, and distribution of new neighborhood data within MESA. Our main objective is to identify unique patterns of neighborhood change related to the causes of prevalence and disparities in cognitive decline and dementia. We will attain our main objective by (aim 1) characterizing dynamic, longitudinal neighborhood social and built environment variables (survey-based and GIS-derived) relevant to cognition for residential addresses of a MESA; (aim 2) examining associations of neighborhood environmental characteristics with cognition and clinically relevant ADRD outcomes; (aim 3) investigate determinants of disparities in ADRD outcomes by socioeconomic position and race/ethnicity and assess the contribution of neighborhood environments. This project is poised to provide robust new evidence about pathways and links between neighborhood environments and cognitive outcomes, with important implications for built environment science, ADRD progression research, and policies to support healthy aging. Aim 1 will create the most comprehensive longitudinal neighborhood dataset on a diverse sample with detailed cognitive and ADRD outcomes for widespread dissemination to a network of researchers. Analyses in aim 2 will contribute to developing substantive theory on the role of neighborhoods in ADRD progression and provide guidance for urban planners to design neighborhoods that support healthy aging. Aim 3 examines component contributions to racial disparities in cognition and ADRD. Through this, we expect to identify actionable, community and clinical interventions to address and remediate racial and socioeconomic inequalities derived from the unequal distribution of environmental supports for healthy aging. We expect this evidence to support and amplify efforts to reduce disparities.
Transactions
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| Amendment | $1,147,726 | $0 | |
| Original award | $1,147,726 | $1,147,726 |
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Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| The Johns Hopkins University | $9,077 | |
| University Of Washington | $58,099 | |
| Regents Of The University Of Minnesota | $61,227 | |
| University Of Washington | $48,227 | |
| The Johns Hopkins University | $9,495 | |
| The Regents Of The University Of California | $9,998 | |
| Wake Forest University Health Sciences | $97,903 | |
| Louisiana State University | $51,815 | |
| University Of Washington | $65,676 | |
| Northwestern University | $17,093 | |
| The Johns Hopkins University | $10,415 | |
| The Trustees Of Columbia University In The City Of New York | $10,000 | |
| Wake Forest University Health Sciences | $51,438 | |
| University Of California, LOS Angeles | $61,867 | |
| The Trustees Of Columbia University In The City Of New York | $85,525 | |
| The Johns Hopkins University | $49,195 | |
| Regents Of The University Of Minnesota | $55,221 | |
| University Of Washington | $55,805 | |
| The Trustees Of Columbia University In The City Of New York | $98,218 |
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Quick answers
Who received award R01AG072634?
R01AG072634 was awarded to Drexel University by National Institute on Aging (National Institutes of Health) on May 15, 2021.
How much is award R01AG072634 worth?
$17,981,697 has been obligated on R01AG072634: $16,833,971 in federal funding and $1,147,726 in non-federal funding.
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