Glucose homeostasis and the risk of alzheimer's disease and alzheimer's disease related dementias in the multi-ethnic study of atherosclerosis

Ended Project Grant Awarded Last action

Award ID
R01AG070881
Recipient
Awarding agency
Obligated
$5,405,206

Award facts

Assistance listing
93.866 Aging Research
Completion date
Place of performance
Columbia, MD 21044, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Alzheimer's disease and alzheimer's disease related dementias pose an enormous public health challenge. In the absence of a cure, prevention or delay of pathology offers the most promising avenue to control the disease. Despite growing recognition that cardiometabolic risk factors are major contributors to cognitive decline, alzheimer's disease, and alzheimer's disease related dementias, many gaps remain in our understanding of the mechanisms and pathways between glucose homeostasis and cognitive function. While type 2 diabetes (T2D) is increasingly recognized as a major preventable risk factor for alzheimer's disease and related dementias, intensive glucose control in T2D has not been shown to prevent cognitive decline in trials. This finding and inconsistent results for the influence of glucose control (HBA1C) on cognitive decline pose the question: what aspects of dysglycemia, and its inverse glucose homeostasis, increase the risk of alzheimer's disease or related dementias? This study's overall goal is to investigate the role of dysglycemia across the glucose spectrum on incident neurocognitive markers of alzheimer's disease and alzheimer's disease related dementias in a multi-ethnic cohort: the multi-ethnic study of atherosclerosis (mesa). Mesa enrolled 6814 men and women beginning in 2000. Mesa participants have been extensively studied with respect to cardiovascular risk factors and outcomes and mesa-mind, a cognitive ancillary, adds comprehensive cognitive testing and neuroimaging including brain MRI and amyloid β pet scans. Mesa has a 7TH exam occurring between 2021-2023 that will be concordant with the second mesa-mind visit. While fasting glucose was obtained at every exam, and HBA1C and homa-IR measured at some exams, continuous glucose has not been measured. Adding continuous glucose monitoring wearable technology to mesa exam 7 and repeated two years later provides a unique and timely opportunity to answer challenging questions about the role of dysglycemia that continue to impede the development of successful prevention strategies for alzheimer's disease and alzheimer's disease related dementias. This study will also add new measurements of insulin resistance (homa-IR). This ancillary to mesa will 1) investigate the antecedent determinants of glucose homeostasis (from continuous glucose monitors at exam 7 (n=2000) and change over two years (n=1000), 2. Determine whether continuous glucose markers of glucose homeostasis, dysglycemia, and change over time are associated with incident neurocognitive indicators of alzheimer's disease or alzheimer's disease related dementias (n=2000), and 3. Investigate the contributions of dysglycemia to alzheimer's disease and related dementia pathologies by SEX and race/ethnicity (n=2000). Findings from this research will identify new mechanisms for the development of alzheimer's disease and alzheimer's disease related dementias, discover new primary and secondary prevention targets, and have the potential to change clinical care.

Transactions

Action Obligated Date
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Amendment $374,952
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Amendment $724,004
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Original award $724,004
Show all 24

Subawards

Subrecipient Amount Awarded
Northwestern University Statement of Work for MESA Field Sites Study title: Glucose homeostasis and cognitive decline Background and objectives Type 2 diabetes (T2D) is a key… $64,782
University Of Washington The research team will work closely with the study Pl (Dr. Morgana Mongraw-Chaffin) and the MESA Coordinating Center to provide work that is consistent with the… $277,688
The Trustees Of Columbia University In The City Of New York Type 2 diabetes (T20) is a key modifiable risk factor for cognitive decline, and increases the risk for Alzheimer's disease and related dementias (ADRD).… $79,464
University Of California, LOS Angeles Background and objectives Type 2 diabetes (T2D) is a key modifiable risk factor for cognitive decline, and increases the risk for Alzheimer's disease and… $107,286
Wake Forest University Study title: Glucose homeostasis and cognitive decline The research team will work closely with the study Pl (Dr. Morgana Mongraw-Chaffin) and the MESA… $614,793
Wake Forest University Health Sciences The research team will work closely with the study Pl (Dr. Morgana Mongraw-Chaffin) and the MESA Coordinating Center to provide work that is consistent with the… $687,040
Regents Of The University Of Minnesota Services to be performed by Field Site The research team will work closely with the study PI (Dr. Morgana Mongraw-Chaffin), the MESA MIND team, and the MESA… $100,755
The Johns Hopkins University The work for this ancillary project by the Johns Hopkins University (JHU) study personnel includes the initial data collection which took place in years 1-3,… $86,075

Quick answers

Who received award R01AG070881?

R01AG070881 was awarded to Medstar Health Research Institute Inc. by National Institute on Aging (National Institutes of Health) on September 30, 2021.

How much is award R01AG070881 worth?

$5,405,206 has been obligated on R01AG070881.

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